Results 81 to 90 of about 16,305 (230)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey [PDF]

Lateral flow (immuno)assays are currently used for qualitative, semiquantitative and to some extent quantitative monitoring in resource-poor or non-laboratory environments.
Amerongen, A., van, Korf, J., Posthuma-Trumpie, G.A.   +2 more
core   +1 more source

An investigation into reducing the spindle acceleration energy consumption of machine tools [PDF]

, 2016
Machine tools are widely used in the manufacturing industry, and consume large amount of energy. Spindle acceleration appears frequently while machine tools are working. It produces power peak which is highly energy intensive. As a result, a considerable
Jia, Shun, Liu, Ying, Lv, Jingxiang, Tang, Renzhong, Tang, Wangchujun, Zhang, Yingfeng   +5 more
core   +2 more sources

Gas Chromatography‐Mass Spectrometry‐Based Phytochemical Profiling and Bioactivity‐Guided Fractionation of Psidium guineense Stem Extracts: In Vitro and In Silico Insights Into Antioxidant, Antidiabetic and Antibacterial Potentials

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Psidium guineense (Myrtaceae) is traditionally used for various medicinal purposes, although its stem remains underexplored. This study provides the first integrated phytochemical, pharmacological and computational evaluation of the stem extracts to elucidate their antioxidant, antidiabetic and antibacterial potential.
Md. Jahid Hossain, Mst. Shagorika Shila, Muhammad Rashedul Islam, Jakir Ahmed Chowdhury   +3 more
wiley   +1 more source

Application of Prostate-Specific Antigen Density and Related Indicators in the Diagnosis of Prostate Cancer and Construction of a Risk Prediction Model

Journal of Bio-X Research
Objectives: To investigate the diagnostic value of prostate-specific antigen density (PSAD), prostate volume (PV), free prostate-specific antigen (fPSA), total prostate-specific antigen (tPSA), and fPSA/tPSA in prostate cancer (PCa) and to construct a ...
Yuanfu Qiu, Lisi Huang, Longqiaozi Sun, Jianfen Lei, Chaohui Duan   +4 more
doaj   +1 more source

A systematic review of the diagnostic accuracy of prostate specific antigen

BMC Urology, 2009
Background Prostate cancer is the fourth commonest cancer in the UK, and the incidence is rising. The reference standard for diagnosing this condition is prostate biopsy, an invasive procedure.
Curtis Ben, Endersby Deborah, Basuita Amman, Harvey Philip, Iacovidou Aphrodite, Walker Mary   +5 more
doaj   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making

Clinical Interventions in Aging, 2014
Ikenna I Nnabugwu,1,2 Fred O Ugwumba,1 Oghenekaro A Enivwenae,2 Emeka I Udeh,1 Chris O Otene,2 Chinwe A Nnabugwu3 1Urology Unit, Department of Surgery, College of Medicine, University of Nigeria, Nsukka, 2Urology Unit, Department of Surgery, 3Department ...
Nnabugwu II, Ugwumba FO, Enivwenae OA, Udeh EI, Otene CO, Nnabugwu CA   +5 more
doaj  

Stability of total prostate-specific antigen and free prostate-specific antigen after 10 years’ storage

The International Journal of Biological Markers, 2018
Introduction: PSA is a serine protease composed of 240 amino acids in a single polypeptide chain and is a routine parameter in prostate cancer diagnostics.
Vaclav Simanek, Ondrej Topolcan, Marie Karlikova, Olga Dolejsova, Radka Fuchsova, Judita Kinkorova, David Slouka, Radek Kucera   +7 more
doaj   +1 more source

Cardioprotective effect of spirulina on cafeteria diet‐induced cardiac injury in silico and in vivo study

Journal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4720-4743, June 2026.
Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari, Mohamed‐Amine Jabri, Imen Hammami, Hichem Sebai   +3 more
wiley   +1 more source