Results 1 to 10 of about 26,453 (308)

Sampling trabecular meshwork using TrabEx+ [PDF]

BMC Ophthalmology, 2021
Background To report sampling of the trabecular meshwork using the TrabEx+ (MicroSurgical Technology, Redmond, Washington, USA) device in ab interno trabeculectomy.
Vipul Ramjiani, Hardeep-Singh Mudhar, Thomas Julian, Graham Auger   +3 more
doaj   +6 more sources

Histopathological changes in the trabecular meshwork in primary congenital glaucoma [PDF]

American Journal of Ophthalmology Case Reports
Purpose: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma. Methods: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients ...
Aparna Rao
doaj   +2 more sources

Characterizing the expression profile of Dexras1 in human trabecular meshwork cells [PDF]

Biochemistry and Biophysics Reports
Corticosteroids are a mainstay therapy for the treatment of ocular and systemic inflammatory conditions but are associated with a significant risk of intraocular pressure elevation, or ocular hypertension.
ChihWei Chen, Jiapeng Han, Luis Sanchez, Judy L. Chen, Jie J. Zheng   +4 more
doaj   +2 more sources

Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles [PDF]

Current Issues in Molecular Biology
Glaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du, Ajay Kumar, Enzhi Yang, Jingxue Zhang, Ningli Wang, Yiqin Du   +5 more
doaj   +2 more sources

The TGFβ Induced MicroRNAome of the Trabecular Meshwork [PDF]

Cells
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex, multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically modifiable risk factor for POAG.
Chelsey Doyle, Breedge Callaghan, Anton W. Roodnat, Lee Armstrong, Karen Lester, David A. Simpson, Sarah D. Atkinson, Carl Sheridan, Declan J. McKenna, Colin E. Willoughby   +9 more
doaj   +2 more sources

Nanotubules and Cellular Communication in Trabecular Meshwork Cells. [PDF]

Methods Mol Biol
Keller KE, Kaech Petrie S.
europepmc   +3 more sources

Integrative analysis of mRNA, lncRNA, circRNA, and miRNA to investigate the anti-fibrotic activity of silibinin in TGF-β2-treated human trabecular meshwork cells. [PDF]

BMC Genomics
Liu J, Wu X, Guo J, Zhou L, Liu X, Zhu L, Ma L, Wang J.   +7 more
europepmc   +3 more sources

Cryo-Electrospinning Generates Highly Porous Fiber Scaffolds Which Improves Trabecular Meshwork Cell Infiltration

Journal of Functional Biomaterials, 2023
Human trabecular meshwork is a sieve-like tissue with large pores, which plays a vital role in aqueous humor outflow. Dysfunction of this tissue can occur, which leads to glaucoma and permanent vision loss.
Devon J. Crouch, Carl M. Sheridan, Julia G. Behnsen, Raechelle A. D’Sa, Lucy A. Bosworth   +4 more
doaj   +1 more source

Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix [PDF]

Investigative Opthalmology & Visual Science, 2015
Treatment with corticosteroids can result in ocular hypertension and may lead to the development of steroid-induced glaucoma. The extent to which biomechanical changes in trabecular meshwork (TM) cells and extracellular matrix (ECM) contribute toward this dysfunction is poorly understood.Primary human TM (HTM) cells were cultured for either 3 days or 4
Vijay Krishna, Raghunathan, Joshua T, Morgan, Shin Ae, Park, Darren, Weber, Brett S, Phinney, Christopher J, Murphy, Paul, Russell   +6 more
openaire   +2 more sources

TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure

PLoS ONE, 2021
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but it is
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Rei Sakata, Megumi Honjo, Makoto Aihara   +7 more
doaj   +2 more sources