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The TGFβ Induced MicroRNAome of the Trabecular Meshwork [PDF]

Cells
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex, multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically modifiable risk factor for POAG.
Chelsey Doyle, Breedge Callaghan, Anton W. Roodnat, Lee Armstrong, Karen Lester, David A. Simpson, Sarah D. Atkinson, Carl Sheridan, Declan J. McKenna, Colin E. Willoughby   +9 more
doaj   +6 more sources

Cryo-Electrospinning Generates Highly Porous Fiber Scaffolds Which Improves Trabecular Meshwork Cell Infiltration

Journal of Functional Biomaterials, 2023
Human trabecular meshwork is a sieve-like tissue with large pores, which plays a vital role in aqueous humor outflow. Dysfunction of this tissue can occur, which leads to glaucoma and permanent vision loss.
Devon J. Crouch, Carl M. Sheridan, Julia G. Behnsen, Raechelle A. D’Sa, Lucy A. Bosworth   +4 more
doaj   +2 more sources

Mesenchymal stem cell-derived exosomes protect trabecular meshwork from oxidative stress

Scientific Reports, 2021
This study aims to investigate the beneficial effects of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on trabecular meshwork cells under oxidative stress and predict candidate genes associated with this process.
Ying-chao Li, Juan Zheng, Xi-zi Wang, Xin Wang, Wen-jing Liu, Jian-lu Gao   +5 more
doaj   +2 more sources

TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure

PLoS ONE, 2021
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but it is
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Rei Sakata, Megumi Honjo, Makoto Aihara   +7 more
doaj   +3 more sources

Histopathological changes in the trabecular meshwork in primary congenital glaucoma [PDF]

American Journal of Ophthalmology Case Reports
Purpose: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma. Methods: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients ...
Aparna Rao
doaj   +2 more sources

Schlemm's Canal and Trabecular Meshwork in Eyes with Primary Open Angle Glaucoma: A Comparative Study Using High-Frequency Ultrasound Biomicroscopy. [PDF]

PLoS ONE, 2016
We investigated in vivo changes in Schlemm's canal and the trabecular meshwork in eyes with primary open angle glaucoma (POAG). Relationships between Schlemm's canal diameter, trabecular meshwork thickness, and intraocular pressure (IOP) were examined ...
Xiaoqin Yan, Mu Li, Zhiqi Chen, Ying Zhu, Yinwei Song, Hong Zhang   +5 more
doaj   +2 more sources

Characterizing the expression profile of Dexras1 in human trabecular meshwork cells [PDF]

Biochemistry and Biophysics Reports
Corticosteroids are a mainstay therapy for the treatment of ocular and systemic inflammatory conditions but are associated with a significant risk of intraocular pressure elevation, or ocular hypertension.
ChihWei Chen, Jiapeng Han, Luis Sanchez, Judy L. Chen, Jie J. Zheng   +4 more
doaj   +2 more sources

Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles [PDF]

Current Issues in Molecular Biology
Glaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du, Ajay Kumar, Enzhi Yang, Jingxue Zhang, Ningli Wang, Yiqin Du   +5 more
doaj   +2 more sources

TPM2 regulates contractility and biomechanical properties in trabecular meshwork cells. [PDF]

Sci Rep
Shen B, Gong Y, Xu Y, Ling Q, Huang R, Jia X.   +5 more
europepmc   +3 more sources

Co-delivery of ripasudil and dexamethasone in trabecular meshwork cells for potential prevention of GC-induced ocular hypertension. [PDF]

Exp Cell Res
Debele TA, Yuan Y, Kao W, Liu CY, Dessie EY, Park YC.   +5 more
europepmc   +2 more sources