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The TGFβ Induced MicroRNAome of the Trabecular Meshwork. [PDF]
CellsPrimary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex, multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically modifiable risk factor for POAG. All current pharmacological agents target aqueous hu-mour dynamics to lower IOP.
Doyle C +9 more
europepmc +7 more sources
Sampling trabecular meshwork using TrabEx+ [PDF]
BMC Ophthalmology, 2021 Abstract Background To report sampling of the trabecular meshwork using the TrabEx+ (MicroSurgical Technology, Redmond, Washington, USA) device in ab interno trabeculectomy. Specifically, this series focusses upon preservation of the trabecular meshwork architecture for assessment of glaucomatous features using common ...
Hardeep-Singh Mudhar +4 more
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Trabecular meshwork stiffness in glaucoma [PDF]
Experimental Eye Research, 2017 Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain data suggest an association between elevated intraocular pressure (IOP) and increased TM stiffness; however, the underlying link between TM stiffness and IOP remains ...
C. Ross Ethier +3 more
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Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix [PDF]
Investigative Opthalmology & Visual Science, 2015 Treatment with corticosteroids can result in ocular hypertension and may lead to the development of steroid-induced glaucoma. The extent to which biomechanical changes in trabecular meshwork (TM) cells and extracellular matrix (ECM) contribute toward this dysfunction is poorly understood.Primary human TM (HTM) cells were cultured for either 3 days or 4
Vijay Krishna Raghunathan +6 more
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Human Trabecular Meshwork Progenitors [PDF]
International Journal of Medical Sciences, 2019 Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwork diseases such as glaucoma, corneal endothelial dysfunctions such as blindness due to corneal endothelial ...
Min Hu +5 more
openaire +3 more sources
Lysyl Oxidases in the Trabecular Meshwork [PDF]
Journal of Glaucoma, 2014 The mechanical properties of the extracellular matrix (ECM) play an important role in maintaining cellular function and overall tissue homeostasis. Emerging evidence suggests that biomechanical modifications of the ECM may be initiators and/or drivers of disease, exemplified by increased tissue stiffness.
Robert J. Wordinger, Abbot F. Clark
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The Role of Integrins in the Trabecular Meshwork [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2014 Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). However, integrins are not just adhesion receptors. They can act as "bidirectional signal transducers" that coordinate a large number of cellular activities in response to the extracellular environment and intracellular signaling ...
Debjani Gagen +3 more
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Role of MicroRNAs in the Trabecular Meshwork [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2014 MicroRNAs (miRNAs) are now recognized as important post-transcriptional regulators of gene expression. MiRNAs are known to modulate cellular functions relevant to the normal and pathological physiology of the trabecular meshwork (TM) such as cell contraction and extracellular matrix turnover.
Guorng Li +4 more
openaire +3 more sources
Stress Response of the Trabecular Meshwork [PDF]
Journal of Glaucoma, 2008 The trabecular meshwork (TM) is known to be subjected to different types of stress such as mechanical, oxidative, and phagocytic stress. Although short-term exposure to these stresses is expected to elicit adaptive responses, long-term exposure may lead to permanent alterations in the tissue physiology and contribute to the pathologic increase in ...
Pedro Gonzalez, Paloma B. Liton
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Extracellular matrix in the trabecular meshwork [PDF]
Experimental Eye Research, 2008 The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is regulated primarily by a fluid resistance to aqueous humor outflow. However, neither the exact site nor the identity of the normal resistance to aqueous humor outflow has been ...
Ted S. Acott, Mary J. Kelley
openaire +2 more sources