Sampling trabecular meshwork using TrabEx+ [PDF]
BMC Ophthalmology, 2021 Background To report sampling of the trabecular meshwork using the TrabEx+ (MicroSurgical Technology, Redmond, Washington, USA) device in ab interno trabeculectomy.
Vipul Ramjiani +3 more
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Histopathological changes in the trabecular meshwork in primary congenital glaucoma [PDF]
American Journal of Ophthalmology Case ReportsPurpose: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma. Methods: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients ...
Aparna Rao
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Characterizing the expression profile of Dexras1 in human trabecular meshwork cells [PDF]
Biochemistry and Biophysics ReportsCorticosteroids are a mainstay therapy for the treatment of ocular and systemic inflammatory conditions but are associated with a significant risk of intraocular pressure elevation, or ocular hypertension.
ChihWei Chen +4 more
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Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles [PDF]
Current Issues in Molecular BiologyGlaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du +5 more
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The TGFβ Induced MicroRNAome of the Trabecular Meshwork [PDF]
CellsPrimary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex, multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically modifiable risk factor for POAG.
Chelsey Doyle +9 more
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Journal of Functional Biomaterials, 2023 Human trabecular meshwork is a sieve-like tissue with large pores, which plays a vital role in aqueous humor outflow. Dysfunction of this tissue can occur, which leads to glaucoma and permanent vision loss.
Devon J. Crouch +4 more
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PLoS ONE, 2021 Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but it is
Takatoshi Uchida +7 more
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Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix [PDF]
Investigative Opthalmology & Visual Science, 2015 Treatment with corticosteroids can result in ocular hypertension and may lead to the development of steroid-induced glaucoma. The extent to which biomechanical changes in trabecular meshwork (TM) cells and extracellular matrix (ECM) contribute toward this dysfunction is poorly understood.Primary human TM (HTM) cells were cultured for either 3 days or 4
Vijay Krishna, Raghunathan +6 more
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Schlemm's Canal and Trabecular Meshwork in Eyes with Primary Open Angle Glaucoma: A Comparative Study Using High-Frequency Ultrasound Biomicroscopy. [PDF]
PLoS ONE, 2016 We investigated in vivo changes in Schlemm's canal and the trabecular meshwork in eyes with primary open angle glaucoma (POAG). Relationships between Schlemm's canal diameter, trabecular meshwork thickness, and intraocular pressure (IOP) were examined ...
Xiaoqin Yan +5 more
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Mesenchymal stem cell-derived exosomes protect trabecular meshwork from oxidative stress
Scientific Reports, 2021 This study aims to investigate the beneficial effects of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on trabecular meshwork cells under oxidative stress and predict candidate genes associated with this process.
Ying-chao Li +5 more
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