Results 11 to 20 of about 78,864 (334)

Trabecular Meshwork [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Integrative analysis of mRNA, lncRNA, circRNA, and miRNA to investigate the anti-fibrotic activity of silibinin in TGF-β2-treated human trabecular meshwork cells. [PDF]

BMC Genomics
Liu J, Wu X, Guo J, Zhou L, Liu X, Zhu L, Ma L, Wang J.   +7 more
europepmc   +3 more sources

Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review

Clinical and Experimental Ophthalmology, 2022
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of the eye. It does this by establishing a tunable outflow resistance, defined by the interplay between cells and their extracellular matrix (ECM) milieu, and the ...
Kate E. Keller, D. M. Peters
semanticscholar   +1 more source

High Glucose-induced transcriptomic changes in human trabecular meshwork cells. [PDF]

Mol Biol Rep
Singh S, Raghavan S, Patel NA, Soundararajan A, Pattabiraman PP.   +4 more
europepmc   +2 more sources

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Primary Open Angle Glaucoma (POAG) is the most common form of glaucoma that leads to irreversible vision loss and blindness worldwide. POAG is often associated with elevated intraocular pressure (IOP).
Pinkal D. Patel, Y. Chen, Ramesh B. Kasetti, Prabhavathi Maddineni, William Mayhew, J. Millar, D. Ellis, Swapnil K. Sonkusare, G. Zode   +8 more
semanticscholar   +1 more source

Establishment of appropriate glaucoma models using dexamethasone or TGFβ2 treated three-dimension (3D) cultured human trabecular meshwork (HTM) cells

Scientific Reports, 2021
To establish appropriate ex vivo models for a glaucomatous trabecular meshwork (TM), two-dimensional (2D) and three-dimensional (3D) cultures of human trabecular meshwork cells (HTM) were prepared in the presence of 250 nM dexamethasone (DEX) or 5 ng/mL ...
Megumi Watanabe, Yosuke Ida, H. Ohguro, Chiaki Ota, Fumihito Hikage   +4 more
semanticscholar   +1 more source

Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The trabecular meshwork is the major tissue regulating intraocular pressure (IOP). Malfunction of this tissue results in ocular hypertension, the major risk factor for glaucoma.
M. Shim, April Nettesheim, Angela Dixon, P. Liton   +3 more
semanticscholar   +1 more source

Zika virus impairs autophagic flux in trabecular meshwork, and inhibition of autophagy restricts ocular viral transmission and associated pathology. [PDF]

Microbiol Spectr
Ahmad F, Kumar P, Singh P, Joshi T, Singh PK.   +4 more
europepmc   +2 more sources

Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG

Aging, 2021
Primary open angle glaucoma (POAG) is the leading cause of irreversible blindness. Dysfunction of the trabecular meshwork (TM), resulting in decreased outflow of aqueous humor and increased intraocular pressure (IOP), plays an important role in the ...
Y. Ying, Ran Xue, Yangfan Yang, Sarah X. Zhang, Hui Xiao, Hua-zhang Zhu, Jingming Li, Guo Chen, Yiming Ye, Minbin Yu, Xing Liu, Yimin Zhong   +11 more
semanticscholar   +1 more source

Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix [PDF]

Investigative Opthalmology & Visual Science, 2015
Treatment with corticosteroids can result in ocular hypertension and may lead to the development of steroid-induced glaucoma. The extent to which biomechanical changes in trabecular meshwork (TM) cells and extracellular matrix (ECM) contribute toward this dysfunction is poorly understood.Primary human TM (HTM) cells were cultured for either 3 days or 4
Vijay Krishna, Raghunathan, Joshua T, Morgan, Shin Ae, Park, Darren, Weber, Brett S, Phinney, Christopher J, Murphy, Paul, Russell   +6 more
openaire   +2 more sources