Results 11 to 20 of about 67,374 (288)
Mesenchymal stem cell-derived exosomes protect trabecular meshwork from oxidative stress
Scientific Reports, 2021 This study aims to investigate the beneficial effects of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on trabecular meshwork cells under oxidative stress and predict candidate genes associated with this process.
Ying-chao Li +5 more
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PLoS ONE, 2021 Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but it is
Takatoshi Uchida +7 more
doaj +3 more sources
Schlemm's Canal and Trabecular Meshwork in Eyes with Primary Open Angle Glaucoma: A Comparative Study Using High-Frequency Ultrasound Biomicroscopy. [PDF]
PLoS ONE, 2016 We investigated in vivo changes in Schlemm's canal and the trabecular meshwork in eyes with primary open angle glaucoma (POAG). Relationships between Schlemm's canal diameter, trabecular meshwork thickness, and intraocular pressure (IOP) were examined ...
Xiaoqin Yan +5 more
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Oxidative stress and antioxidants in the trabecular meshwork
PeerJ, 2019 Glaucoma is an age-dependent disease closely related to oxidative stress and is regarded as the second leading cause of irreversible blindness worldwide. In recent years, many studies have shown that morphological and functional abnormalities of the trabecular meshwork (TM) are closely related to glaucoma, especially with respect to oxidative stress ...
Yajuan Zheng, Mingxuan Wang
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NODULAR DYSTROPHY OF THE TRABECULAR MESHWORK [PDF]
British Journal of Ophthalmology, 1962 J. S. Speakman
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Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review
Clinical and Experimental Ophthalmology, 2022 The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of the eye. It does this by establishing a tunable outflow resistance, defined by the interplay between cells and their extracellular matrix (ECM) milieu, and the ...
Kate E. Keller, D. M. Peters
semanticscholar +1 more source
Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Primary Open Angle Glaucoma (POAG) is the most common form of glaucoma that leads to irreversible vision loss and blindness worldwide. POAG is often associated with elevated intraocular pressure (IOP).
Pinkal D. Patel +8 more
semanticscholar +1 more source
Scientific Reports, 2021 To establish appropriate ex vivo models for a glaucomatous trabecular meshwork (TM), two-dimensional (2D) and three-dimensional (3D) cultures of human trabecular meshwork cells (HTM) were prepared in the presence of 250 nM dexamethasone (DEX) or 5 ng/mL ...
Megumi Watanabe +4 more
semanticscholar +1 more source
Scientific Reports, 2021 The trabecular meshwork (TM) constitutes the main pathway for aqueous humor drainage and is exposed to complex intraocular pressure fluctuations. The mechanism of homeostasis in which TM senses changes in intraocular pressure and leads to normal levels ...
Takatoshi Uchida +6 more
semanticscholar +1 more source
Journal of Functional Biomaterials, 2023 Human trabecular meshwork is a sieve-like tissue with large pores, which plays a vital role in aqueous humor outflow. Dysfunction of this tissue can occur, which leads to glaucoma and permanent vision loss.
Devon J. Crouch +4 more
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