Results 21 to 30 of about 78,864 (334)

Mechanical stretch induces Ca2+ influx and extracellular release of PGE2 through Piezo1 activation in trabecular meshwork cells

Scientific Reports, 2021
The trabecular meshwork (TM) constitutes the main pathway for aqueous humor drainage and is exposed to complex intraocular pressure fluctuations. The mechanism of homeostasis in which TM senses changes in intraocular pressure and leads to normal levels ...
Takatoshi Uchida, Shota Shimizu, R. Yamagishi, Suzumi M. Tokuoka, Y. Kita, M. Honjo, M. Aihara   +6 more
semanticscholar   +1 more source

Sampling trabecular meshwork using TrabEx+

BMC Ophthalmology, 2021
Background To report sampling of the trabecular meshwork using the TrabEx+ (MicroSurgical Technology, Redmond, Washington, USA) device in ab interno trabeculectomy.
Vipul Ramjiani, Hardeep-Singh Mudhar, Thomas Julian, Graham Auger   +3 more
doaj   +1 more source

Nanotubules and Cellular Communication in Trabecular Meshwork Cells. [PDF]

Methods Mol Biol
Keller KE, Kaech Petrie S.
europepmc   +3 more sources

Distribution of Gold Nanoparticles in the Anterior Chamber of the Eye after Intracameral Injection for Glaucoma Therapy

Pharmaceutics, 2021
In glaucoma therapy, nanoparticles (NPs) are a favorable tool for delivering drugs to the outflow tissues of the anterior chamber of the eye where disease development and progression take place.
Tobias Sonntag, Franziska Froemel, W. Daniel Stamer, Andreas Ohlmann, Rudolf Fuchshofer, Miriam Breunig   +5 more
doaj   +1 more source

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Nature Communications, 2021
Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM), which controls the outflow of aqueous humor (AqH) from the anterior ...
K. S. Nair, Chitrangda Srivastava, Robert V Brown, Swanand Koli, H. Choquet, H. S. Kang, Y. Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. A. Johnson, Yin-yin Zhao, J. Yin, K. Okamoto, Graham M. Clark, Terete Borrás, G. Zode, K. Kizhatil, S. Chakrabarti, S. John, E. Jorgenson, A. Jetten   +21 more
semanticscholar   +1 more source

Lysyl Oxidases in the Trabecular Meshwork [PDF]

Journal of Glaucoma, 2014
The mechanical properties of the extracellular matrix (ECM) play an important role in maintaining cellular function and overall tissue homeostasis. Emerging evidence suggests that biomechanical modifications of the ECM may be initiators and/or drivers of disease, exemplified by increased tissue stiffness.
Robert J, Wordinger, Abbot F, Clark
openaire   +2 more sources

Trabecular meshwork's collagen network formation is inhibited by non‐pigmented ciliary epithelium‐derived extracellular vesicles

Journal of Cellular and Molecular Medicine, 2021
The present research aims to determine whether the application of non‐pigmented ciliary epithelium cells derived extracellular vesicles to human trabecular meshwork cells affects the formation and secretion of collagen type I to the extracellular matrix ...
Saray Tabak, S. Schreiber-Avissar, E. Beit-Yannai   +2 more
semanticscholar   +1 more source

Human Trabecular Meshwork Progenitors [PDF]

International Journal of Medical Sciences, 2019
Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwork diseases such as glaucoma, corneal endothelial dysfunctions such as blindness due to corneal endothelial ...
Zhu, Qin, Zhang, Yuan, Tighe, Sean, Liu, Yongsong, Zhu, Yingting, Hu, Min   +5 more
openaire   +2 more sources

Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis. [PDF]

PLoS ONE, 2015
A traditional Chinese medicine, Tetramethylpyrazine (TMP), has been prescribed as a complementary treatment for glaucoma to improve patient prognosis. However, the pharmacological mechanism of action of TMP is poorly understood.
Na Yu, Zhang Zhang, Pei Chen, Yimin Zhong, Xiaoxiao Cai, Huan Hu, Ying Yang, Jing Zhang, Kaijing Li, Jian Ge, Keming Yu, Xing Liu, Jing Zhuang   +12 more
doaj   +1 more source

Trabecular meshwork stiffness in glaucoma [PDF]

Experimental Eye Research, 2017
Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain data suggest an association between elevated intraocular pressure (IOP) and increased TM stiffness; however, the underlying link between TM stiffness and IOP remains ...
Ke, Wang, A Thomas, Read, Todd, Sulchek, C Ross, Ethier   +3 more
openaire   +2 more sources