Results 21 to 30 of about 67,374 (288)

Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG

Aging, 2021
Primary open angle glaucoma (POAG) is the leading cause of irreversible blindness. Dysfunction of the trabecular meshwork (TM), resulting in decreased outflow of aqueous humor and increased intraocular pressure (IOP), plays an important role in the ...
Y. Ying, Ran Xue, Yangfan Yang, Sarah X. Zhang, Hui Xiao, Hua-zhang Zhu, Jingming Li, Guo Chen, Yiming Ye, Minbin Yu, Xing Liu, Yimin Zhong   +11 more
semanticscholar   +1 more source

GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans

Nature Communications, 2021
Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM), which controls the outflow of aqueous humor (AqH) from the anterior ...
K. S. Nair, Chitrangda Srivastava, Robert V Brown, Swanand Koli, H. Choquet, H. S. Kang, Y. Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. A. Johnson, Yin-yin Zhao, J. Yin, K. Okamoto, Graham Clark, Terete Borrás, G. Zode, K. Kizhatil, S. Chakrabarti, S. John, E. Jorgenson, A. Jetten   +21 more
semanticscholar   +1 more source

Trabecular meshwork's collagen network formation is inhibited by non‐pigmented ciliary epithelium‐derived extracellular vesicles

Journal of Cellular and Molecular Medicine, 2021
The present research aims to determine whether the application of non‐pigmented ciliary epithelium cells derived extracellular vesicles to human trabecular meshwork cells affects the formation and secretion of collagen type I to the extracellular matrix ...
Saray Tabak, S. Schreiber-Avissar, E. Beit-Yannai   +2 more
semanticscholar   +1 more source

Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis. [PDF]

PLoS ONE, 2015
A traditional Chinese medicine, Tetramethylpyrazine (TMP), has been prescribed as a complementary treatment for glaucoma to improve patient prognosis. However, the pharmacological mechanism of action of TMP is poorly understood.
Na Yu, Zhang Zhang, Pei Chen, Yimin Zhong, Xiaoxiao Cai, Huan Hu, Ying Yang, Jing Zhang, Kaijing Li, Jian Ge, Keming Yu, Xing Liu, Jing Zhuang   +12 more
doaj   +1 more source

Distribution of Gold Nanoparticles in the Anterior Chamber of the Eye after Intracameral Injection for Glaucoma Therapy

Pharmaceutics, 2021
In glaucoma therapy, nanoparticles (NPs) are a favorable tool for delivering drugs to the outflow tissues of the anterior chamber of the eye where disease development and progression take place.
Tobias Sonntag, Franziska Froemel, W. Daniel Stamer, Andreas Ohlmann, Rudolf Fuchshofer, Miriam Breunig   +5 more
doaj   +1 more source

Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. [PDF]

PLoS ONE, 2016
Exosomes are emerging as important mediators of cell-matrix interactions by means of specific adhesion proteins. Changes in the tissue-specific exosomal protein expression may underlie pathological conditions whereby extracellular matrix turnover and ...
W Michael Dismuke, Mikael Klingeborn, W Daniel Stamer   +2 more
doaj   +1 more source

Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow

Journal of Physiology, 2020
Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that regulates intraocular pressure through the control of aqueous humour drainage.
O. Yarishkin, Tam T. T. Phuong, Jackson M. Baumann, Michael L. De Ieso, F. Vázquez-Chona, Christopher N. Rudzitis, Chad Sundberg, Mónika Lakk, W. D. Stamer, D. Križaj   +9 more
semanticscholar   +1 more source

Transplantation of iPSC-TM stimulates division of trabecular meshwork cells in human eyes

Scientific Reports, 2020
The trabecular meshwork’s (TM) physiological role is to maintain normal intraocular pressure by regulating aqueous humor outflow. With age, and particularly in eyes with primary open angle glaucoma, the number of cells residing within the TM is markedly ...
Wei Zhu, Cheyanne R Godwin, Lin Cheng, T. Scheetz, M. Kuehn   +4 more
semanticscholar   +1 more source

Cystatin a, a potential common link for mutant myocilin causative glaucoma. [PDF]

PLoS ONE, 2012
Myocilin (MYOC) is a 504 aa secreted glycoprotein induced by stress factors in the trabecular meshwork tissue of the eye, where it was discovered. Mutations in MYOC are linked to glaucoma.
K David Kennedy, S A AnithaChristy, Lakisha K Buie, Teresa Borrás   +3 more
doaj   +1 more source

Adipose‐derived stem cells integrate into trabecular meshwork with glaucoma treatment potential

The FASEB Journal, 2020
The trabecular meshwork (TM) is an ocular tissue that maintains intraocular pressure (IOP) within a physiologic range. Glaucoma patients have reduced TM cellularity and, frequently, elevated IOP.
Yi Zhou, X. Xia, Enzhi Yang, Yiwen Wang, K. Marra, C. Ethier, J. Schuman, Yiqin Du   +7 more
semanticscholar   +1 more source