Results 141 to 150 of about 9,645,786 (257)

Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations

Human Genomics
Trace Amine Associated Receptor 1 (TAAR1) is a novel pharmaceutical target under investigation for the treatment of several neuropsychiatric conditions.
Britto Shajan, Shashikanth Marri, Tarun Bastiampillai, Karen J. Gregory, Shane D. Hellyer, Pramod C. Nair   +5 more
doaj   +1 more source

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +2 more sources

Publisher Correction to: Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques. [PDF]

Neuropsychopharmacology, 2023
Goonawardena AV, Morairty SR, Dell R, Orellana GA, Hoener MC, Wallace TL, Kilduff TS.   +6 more
europepmc   +1 more source

Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors. [PDF]

J Headache Pain, 2023
Zhang Y, Wang H, Sun Y, Huang Z, Tao Y, Wang Y, Jiang X, Tao J.   +7 more
europepmc   +1 more source

Ulotaront, a Trace Amine-Associated Receptor 1/Serotonin 5-HT_1A Agonist, in Patients With Parkinson Disease Psychosis: A Pilot Study. [PDF]

Neurol Clin Pract, 2023
Isaacson SH, Goldstein M, Pahwa R, Singer C, Klos K, Pucci M, Zhang Y, Crandall D, Koblan KS, Navia B, Parkinson's Psychosis TAAR1 Study Group.   +10 more
europepmc   +1 more source

Metabolic and cardiovascular benefits and risks of 4-hydroxy guanabenz hydrochloride: α₂-adrenoceptor and trace amine-associated receptor 1 ligand. [PDF]

Pharmacol Rep, 2023
Kotańska M, Marcinkowska M, Kuder KJ, Walczak M, Bednarski M, Siwek A, Kołaczkowski M.   +6 more
europepmc   +1 more source

Structural insights on the ligand selectivity of the mouse trace amine-associated receptor TAAR7e. [PDF]

iScience
Liu Y, He J, Sun J, Zhang C, Zhuang H, Song J, Shi P, Liu W.   +7 more
europepmc   +1 more source

Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist. [PDF]

ACS Chem Neurosci, 2022
Decker AM, Brackeen MF, Mohammadkhani A, Kormos CM, Hesk D, Borgland SL, Blough BE.   +6 more
europepmc   +1 more source

Protein Metabolism Changes and Alterations in Behavior of Trace Amine-Associated Receptor 1 Knockout Mice Fed a High-Fructose Diet. [PDF]

Neurol Int, 2023
Apryatin SA, Zhukov IS, Zolotoverkhaya EA, Kuvarzin SR, Khunagov TA, Ushmugina SV, Klimenko VM.   +6 more
europepmc   +1 more source

The Role of Trace Amine-Associated Receptor 1 (TAAR1) in the Pathophysiology and Treatment of Depression. [PDF]

Curr Neuropharmacol
Guan W.
europepmc   +1 more source