Results 181 to 190 of about 9,645,786 (257)

The trace amine-associated receptor 1 agonists - non-dopaminergic antipsychotics or covert modulators of D2 receptors? [PDF]

J Psychopharmacol
Reynolds GP.
europepmc   +1 more source

Efficient Light‐Driven Multi‐Electron Accumulation on Viologens by Molecular Control Over Photochemical Reaction Pathways

Chemistry – A European Journal, EarlyView.
Minimum structural changes, maximum output: By either utilizing a more oxidizing Ru(II) polypyridyl chromophore or by using a more reducing SED, the photocatalytic reduction of methyl viologen (MV2+) proceeds via a reductive quenching pathway. This not only significantly accelerates the overall photoreduction process but also allows accumulation of ...
Fatemeh Sousani, Georgina E. Shillito, Alexander K. Mengele, Martin D. Hager, Ulrich S. Schubert, Stefanie Gräfe, Stephan Kupfer, Sven Rau   +7 more
wiley   +1 more source

Targeting Cancer Cells With Self‐Assembled Ru‐Polysaccharide Photocatalyst for Visible‐Light‐Induced Activation of Prodrugs

Chemistry – A European Journal, EarlyView.
Self‐assembled photocatalyst Ru(Ada‐bpy)(bpy)2⊂HACD targets cancer cells and catalyzes the prodrug to drug upon exposure to visible light, providing spatially and temporally control in cancer cells. This strategy achieves efficient, controllable, and targeted activation of prodrugs within cancer cells, laying the foundation of effectively reducing the ...
Jianghua Liu, Dinghao Wu, Alexander Kros, Joost N. H. Reek   +3 more
wiley   +1 more source

Readily Accessible bTurea‐Derived Nitroxide Polarizing Agents for Dynamic Nuclear Polarization: bcTCOOKs and bcTmols

Chemistry – A European Journal, EarlyView.
Two families of bTurea‐derived biradicals, bcTmols and bcTCOOKs, were prepared as polarizing agents for dynamic nuclear polarization (DNP)‐enhanced NMR through short and efficient synthetic routes. The best‐performing biradical, bcTCOOK‐M2, containing two methyl groups on the urea bridge, provided signal enhancements of up to ∼220 at 14.1 T and 100 K ...
Ancy T. Wilson, Shubha S. Gunaga, Frederic Mentink‐Vigier, Snorri Th. Sigurdsson   +3 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

In Vitro Activation of Human Adrenergic Receptors and Trace Amine-Associated Receptor 1 by Phenethylamine Analogues Present in Food Supplements. [PDF]

Nutrients
Pinckaers NET, Blankesteijn WM, Mircheva A, Shi X, Opperhuizen A, Schooten FV, Vrolijk MF.   +6 more
europepmc   +1 more source

Trends and Future Directions in Organic Chemistry for Drug Discovery

Chemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source

Boron Monofluoride Complexes Bearing π‐Expanded Coumarin Subunits: Facile Synthesis, Crystal Structure, and Solid‐State Enhanced Emission

Chemistry – A European Journal, EarlyView.
We here report the design, facile synthesis, experimental, and theoretical characterization of a novel class of monofluoroborate compounds featuring π‐expanded coumarin subunits displaying solid‐state enhanced Emission. The origin of this phenomenon is disclosed by combined theoretical and spectroscopic investigations.
Amine Assel, Fausto Puntoriero, Mohamed Chellegui, Antonio Santoro, Francesco Nicolò, Mayssa Zayene, Hichem Ben Jannet, Alessandro Auditore, Tianhong Yan, Alessandro Amadeo, Frédéric Labat, Ilaria Ciofini, Sebastiano Campagna   +12 more
wiley   +1 more source

Asymmetric Activation of Tropos Biphenolic Moieties by Isohexides: An Integrated Computational‐Experimental Approach

Chemistry – A European Journal, EarlyView.
The integrated experimental‐computational study on the asymmetric activation exerted by isohexides on tropos tetra‐aryl moieties embedded in a chiral macrocyclic architecture resulted in a complete definition of the stereochemical as well as stereodynamic features of the macrocyclic final compounds.
Giuseppe Fulvetti, Klara Mali, Filippo Lipparini, Anna Iuliano   +3 more
wiley   +1 more source

Quantitative in vitro-to-in vivo extrapolation of human adrenergic and trace amine-associated receptor 1 potencies of pre-workout supplement ingredients using physiologically based kinetic modelling-based reverse dosimetry. [PDF]

Arch Toxicol
Pinckaers NET, Blankesteijn WM, Mircheva A, Punt A, Opperhuizen A, van Schooten FJ, Vrolijk M.   +6 more
europepmc   +1 more source