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Uncertainty-aware traction force microscopy. [PDF]
PLoS Computational BiologyTraction Force Microscopy (TFM) is a versatile tool to quantify cell-exerted forces by imaging and tracking fiduciary markers embedded in elastic substrates. The computations involved in TFM are often ill-conditioned, and data smoothing or regularization
Adithan Kandasamy +4 more
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Astigmatic traction force microscopy (aTFM) [PDF]
Nature Communications, 2021 Quantifying rapidly progressing three-dimensional forces generated by cells remains a major challenge in mechanobiology. Here, the authors show that combining traction force microscopy with astigmatic imaging permits sensitive out-of-plane force ...
Di Li +8 more
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Dynamic response of the cell traction force to osmotic shock [PDF]
Microsystems & Nanoengineering, 2023 Osmotic pressure is vital to many physiological activities, such as cell proliferation, wound healing and disease treatment. However, how cells interact with the extracellular matrix (ECM) when subjected to osmotic shock remains unclear.
Yongman Liu +6 more
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What are the key factors influencing traction force in postless hip arthroscopy: a retrospective case-control study [PDF]
BMC Musculoskeletal DisordersBackground Perineal post countertraction during hip arthroscopy risks complications. Postless traction avoids the perineal post but requires understanding the factors influencing traction force to optimize safety. This study investigated how gender, body
Guanying Gao +4 more
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A primer to traction force microscopy. [PDF]
J Biol Chem, 2022 Traction force microscopy (TFM) has emerged as a versatile technique for the measurement of single-cell-generated forces. TFM has gained wide use among mechanobiology laboratories, and several variants of the original methodology have been proposed. However, issues related to the experimental setup and, most importantly, data analysis of cell traction ...
Zancla A +4 more
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Measuring (biological) materials mechanics with atomic force microscopy. 5. Traction force microscopy (cell traction forces). [PDF]
Microsc Res Tech, 2023 AbstractCells generate traction forces to probe the mechanical properties of the surroundings and maintain a basal equilibrium state of stress. Traction forces are also implicated in cell migration, adhesion and ECM remodeling, and alteration of these forces is often observed in pathologies such as cancer.
Gil-Redondo JC +3 more
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Field Guide to Traction Force Microscopy. [PDF]
Cell Mol BioengAbstract Introduction Traction force microscopy (TFM) is a widely used technique to measure cell contractility on compliant substrates that mimic the stiffness of human tissues. For every step in a TFM workflow, users make choices which impact the quantitative results, yet many times the rationales and consequences for ...
Denisin AK +3 more
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Journal of Biomechanical Science and Engineering, 2017 Adherent cells generate traction forces, which are generated by and transmitted along the actin cytoskeleton to the underlying external substrate via focal adhesions. These cell generated forces are fundamental for maintaining cell shape and driving cell
Akira TSUKAMOTO +4 more
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High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy [PDF]
Communications BiologyA critical requirement for studying cell mechanics is three-dimensional assessment of cellular shapes and forces with high spatiotemporal resolution. Traction force microscopy with fluorescence imaging enables the measurement of cellular forces, but it ...
Moosung Lee +7 more
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Sensors, 2022 Based on our direct shear creep experiment and the direct shear rheological constitutive model, a semi-empirical time-dependent parameter of the shear strength is obtained by Mohr–Coulomb shear strength theory, and different time-dependent traction force
Wei Yi, Feng Xu
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