Results 51 to 60 of about 194,552 (244)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Effective Teaching in a Humanities and Languages Foundation Year: Lessons Learned from Teaching During a Pandemic.

PRISM
This paper will explore key research around Foundation year entry at a large Northwest university in England, UK and explore what makes effective provision.
Helen Hewertson
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Perceived social support and Chinese university students’ intentions to participate in non-traditional sports: a moderated chain mediation model

Frontiers in Psychology
AimThis study investigates how perceived social support influences Chinese university students’ willingness to participate in non-traditional sports, focusing on the chain mediating roles of psychological resilience and self-efficacy, and the moderating ...
Ying Zhang, Mengkai Wang, Yongtao Zhang
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Unconventional medical practices among Ghanaian students: A university-based survey

Journal of Traditional and Complementary Medicine, 2017
Research on unconventional medical practices among students has proliferated lately in the global space, hitherto, little is known explicitly in Ghana.
Razak Mohammed Gyasi, Williams Agyemang-Duah, Charlotte Monica Mensah, Francis Arthur, Roselyn Torkornoo, Padmore Adusei Amoah   +5 more
doaj   +1 more source

Non-traditional stable isotopes

, 2017
The development of multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS) makes it possible to precisely measure non-traditional stable isotopes.
Dauphas, Nicolas, Teng, Fang Zhen, Watkins, James M.   +2 more
core  

Paramedic students working in snow resort medical clinics: a non-traditional interprofessional clinical placement model [PDF]

, 2019
This study investigates the experiences of undergraduate paramedic students completing interprofessional clinical placements in snow sport injury clinics. Qualitative methods were used to investigate the experiences of participants (n=6) undertaking  non-
Devenish, Anthony Scott, McKay, Glenn, Horrocks, Peter David, Long, David Nicholas, Smith, Michael   +4 more
core   +1 more source