Results 41 to 50 of about 3,154,939 (307)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Developing a transparent reporting tool for AI-based diagnostic prediction models of disease and syndrome in Chinese medicine: a Delphi protocol

Frontiers in Digital Health
IntroductionThe application of artificial intelligence in diagnostic prediction models for diseases and syndromes in Chinese Medicine (CM) has been rapidly expanding, accompanied by a significant increase in related research publications.
Jieyun Li, Jieyun Li, Wei Song Seetoh, Jiekee Lim, Jiekee Lim, Xin’ang Xiao, Xin’ang Xiao, Kehu Yang, Si Yong Yeo, Boyun Sun, Jinhua Liu, Zhaoxia Xu, Zhaoxia Xu, Linda L. D. Zhong   +13 more
doaj   +1 more source

Can Gamified Assessment Replace Traditional Tests? [PDF]

Humanities and Social Sciences Letters, 2018
This paper analyzes the potential of gamified tests as a replacement for conventional tests, and the benefits and challenges of the application of gamification in universities and colleges. It looks into the pros and cons of the use of gamification in higher education, reviews the application of gaming elements in assessments and suggests that the ...
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Quality Assessment of Traditional Persian Medicine Observational StudiesQuality Assessment of Traditional Persian Medicine Observational Studies

Iranian Journal of Public Health
Background: Although observational studies are valuable sources of scientific evidence, they are prone to bias and confounding. This study aimed to assess the quality of observational studies in Traditional Persian medicine (TPM). Methods: A systematic search was conducted in national and international databases up to the end of 2022 to identify ...
Mojtaba Norouzi, Ali Akbar Haghdoost, Mohammad Setayesh   +2 more
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Computers, the internet, and cheating among secondary school students: Some implications for educators [PDF]

, 2004
This article investigates in greater depth one particular aspect of cheating within secondary education and some implications for measuring academic achievement.
Conradson, Stacey, Hernández-Ramos, Pedro F.   +1 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito

Cogent Food & Agriculture
Pouteria caimito is a commercially valuable tropical fruit tree and has medicinal effects in Brazilian folklore. In this thesis, thirteen compounds were isolated for the first time from the fruit of P.
Hai-Yue Zhao, Hao-Yue Zhu, Qing Tang, Qiang Lin, Yi-Kun Hao, Hui-Lin Ou, Tian-Yuan Wu, Wen-Sheng Xuan, Hai-Peng Zhang, Baifu Qin, Yu-Bo Zhang, Jing-Hao Wang, Guo-Cai Wang   +12 more
doaj   +1 more source

The Evolution of Student Engagement: Writing Improves Teaching in Introductory Biology [PDF]

, 2021
In response to calls for pedagogical reforms in undergraduate biology courses to decrease student attrition rates and increase active learning, this article describes one faculty member’s conversion from traditional teaching methods to more engaging ...
Camfield, Eileen, Land, Kirkwood
core   +1 more source