Results 31 to 40 of about 7,969,703 (297)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Field Notes: News from Traditional Arts Indiana [PDF]

, 2005
This issue of Field Notes introduces the State Fair Masters, the Piecemakers, master quilters, and the Huber Family, master winemakers. There is also a report on TAI Day at the Indiana State Fair, featuring musical performances and the Fiddle Contest ...
Traditional Arts Indiana
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Changing Assessment Practice: Process, Principles and Standards [PDF]

, 2008
This is a brief account of what has been learned during the Analysis and Review of Innovations in Assessment (ARIA) project about how changes in assessment practice may be brought about most eff ectively.
Gardner, John, Stobart, Gordon, Harlen, Wynne, Hayward, Louise   +3 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Traditional Arts Indiana Apprenticeship Program 2020-2022

, 2022
A booklet produced that reviews the apprenticeship activities of Traditional Arts Indiana between 2020 and 2022. Dale Drake and Andrea Baughman, Tatting Lace, 2020 Justin Rothshank and Sadie Misiuk, Wood-Fired Pottery, 2020 Keith Ruble, Luke, Andy, and ...
Traditional Arts Indiana, Kay, Jon
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Interpretable multi-center machine learning model driven by facial image features for non-invasive early risk assessment of lung cancer

Frontiers in Physiology
BackgroundEarly identification of lung cancer is critical for improving patient survival and prognosis. Conventional pathological biopsy is invasive, and computed tomography (CT) involves ionizing radiation risks.
Yulin Shi, Yulin Shi, Yi Chun, Shuyi Zhang, Xiaoyan Xu, Wenlian Chen, Lijing Jiao, Lixin Wang, Liping Tu, Liping Tu, Jiatuo Xu, Jiatuo Xu, Jiatuo Xu   +12 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source