Results 51 to 60 of about 890,547 (267)

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage

Frontiers in Pharmacology
Chemical overexposure is a significant concern in both environmental and occupational settings, often leading to oxidative stress and subsequent cellular damage.
Faming Jiang, Faming Jiang, Xiaoyan Huang, Xiaoyan Huang, Xingying Chen, Xingying Chen, Yuanhua Xian   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Applications and challenges of traditional Chinese medicine in gastrointestinal disease treatment: A review

Journal of Traditional Chinese Medical Sciences
Gastrointestinal (GI) diseases are common multifactorial disorders involving chronic inflammation, epithelial barrier disruption, immune dysregulation, gut microbiota imbalance, and abnormalities in motility and gut–brain interactions.
Aijing Li, Liufang Hu, Liangliang He, Ping Yu   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Anti-inflammatory lindenane-type sesquiterpenoid homo-/heterodimers from Chloranthus holostegius: Isolation, structural elucidation, and regulation of NF-κB/JAK pathways

Industrial Crops and Products
Chloranthus holostegius, a perennial herbaceous plant of the family Chloranthaceae, is predominantly distributed in southern China and exhibits significant value in both horticultural and medicinal applications. In this study, nine previously undescribed
Zhao-Chun Zhan, Qiang Lin, Mei-Ting Weng, Miao Wang, Ting-Ting Xu, Yue-Hao Huang, Hui-Hui Zhu, Ting Lu, Yao-Lan Li, Wen Li, Xin Luo, Yi-Wen Zhang, Yu-Bo Zhang, Guo-Cai Wang   +13 more
doaj   +1 more source

Widespread increase of functional connectivity in Parkinson’s disease with tremor: A resting-state fMRI study

Frontiers in Aging Neuroscience, 2015
Parkinson’s disease (PD) is a clinically heterogeneous disease in the symptomatology dominated by tremor, akinesia or rigidity. Focusing on PD patients with tremor, this study investigated their discoordination patterns of spontaneous brain activity by ...
Delong eZhang, Delong eZhang, Xian eLiu, Jun eChen, Bo eLiu, Jinhui eWang, Jinhui eWang   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Advances in Small-Molecule C-KIT/PDGFRα Inhibitors for the Treatment of Gastrointestinal Stromal Tumors

Pharmaceutical Fronts
Stem cell factor receptor (C-KIT) or platelet-derived growth factor receptor α (PDGFRα) gene mutations have been identified as oncogenic drivers for most gastrointestinal stromal tumors (GISTs).
Xuan Zheng, Hong Liang, Yang Zhou, Xiaoyun Lu   +3 more
doaj   +1 more source