Results 41 to 50 of about 890,547 (267)

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science
The limited efficacy and slow onset of current antidepressants underscore the urgent need for novel therapeutic strategies. Here, we established a novel zebrafish inflammation‐based screening model and identified 18β‐glycyrrhetinic acid (18β‐GA) as a ...
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
doaj   +1 more source

Anti-inflammatory and antiviral activities of compounds from the fruit of Pouteria caimito

Cogent Food & Agriculture
Pouteria caimito is a commercially valuable tropical fruit tree and has medicinal effects in Brazilian folklore. In this thesis, thirteen compounds were isolated for the first time from the fruit of P.
Hai-Yue Zhao, Hao-Yue Zhu, Qing Tang, Qiang Lin, Yi-Kun Hao, Hui-Lin Ou, Tian-Yuan Wu, Wen-Sheng Xuan, Hai-Peng Zhang, Baifu Qin, Yu-Bo Zhang, Jing-Hao Wang, Guo-Cai Wang   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The structure of rhizosphere microbial and endophytic communities of Coptis chinensis var. brevisepala: variations across different ecological niches

Frontiers in Microbiology
Coptis chinensis var. brevisepala is a valuable traditional Chinese medicinal plant, whose resources are severely depleted due to long-term overexploitation.
Cuiting Chen, Cuiting Chen, Cuiting Chen, Pan Wang, Genping Tong, Rubing Chen, Rubing Chen, Rubing Chen, Rubing Chen, Yanghui Shen, Xiaojun Wu, Xiaojun Wu, Xiaojun Wu, Weiqing Liang, Weiqing Liang, Weiqing Liang, Jinbao Pu, Jinbao Pu, Jinbao Pu   +18 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Validation of Madecassoside Synergy Significantly Enhanced Cryptotanshinone’s Therapeutic Efficacy Against Acne Vulgaris

Bioengineering
Current acne therapies face major limitations, including antibiotic resistance and skin irritancy. In this study, a synergistic strategy combining cryptotanshinone and madecassoside was developed through functional complementarity. Antibacterial activity
Yaling Guo, Xiaobin Yang, Lifeng Tang, Tao Liang, Rongshen Xiao, Qiang Liu   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

E-assessment-beyond the traditional assessment in digital environment

IOP Conference Series: Materials Science and Engineering, 2021
Abstract An assessment is an integral part of the learning process, which determines whether and to what extent the learning objectives have been achieved. It indicates whether the used tools, technologies and pedagogical approaches have produced positive results.
openaire   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Crystal structure of 6–O,8–O-ditigloyl-6β,8α,11-trihydroxygermacra-1(10)E,4E-diene, C25H38O5

Zeitschrift für Kristallographie - New Crystal Structures
C25H38O5, orthorhombic, P212121, a = 8.80210(10) Å, b = 10.91830(10) Å, c = 24.8521(2) Å, V = 2388.39(4) Å3, Z = 4, Rgt(F) = 0.0340, wRref(F2) = 0.0930, T = 170 K.
Liu Feng, Weng Mei-Ting, Wang Miao, Zhan Zhao-Chun, Wang Guo-Cai   +4 more
doaj   +1 more source