Results 41 to 50 of about 3,204,056 (304)

Using new and innovative technologies to assess clinical stage in early intervention youth mental health services: Evaluation study [PDF]

, 2018
Background: Globally there is increasing recognition that new strategies are required to reduce disability due to common mental health problems. As 75% of mental health and substance use disorders emerge during the teenage or early adulthood years, these
Cross, Shane, Davenport, Tracey A, Hickie, Ian B, Iorfino, Frank, Ospina-Pinillos, Laura, Scott, Elizabeth M, Tickell, Ashleigh   +6 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Global Warming Potential of Building Materials: An Application of Life Cycle Analysis in Nepal [PDF]

, 2017
open6siThis paper analyzes the global-warming potential of materials used to construct the walls of 3 building types—traditional, semimodern, and modern—in Sagarmatha National Park and Buffer Zone in Nepal, using the life-cycle assessment approach ...
Francesca Pierobon, Michela Zanetti, Paola Gatto, Raffaele Cavalli, Ramesh Kumar Maskey, Silu Bhochhibhoya   +5 more
core   +4 more sources

Can Gamified Assessment Replace Traditional Tests? [PDF]

Humanities and Social Sciences Letters, 2018
This paper analyzes the potential of gamified tests as a replacement for conventional tests, and the benefits and challenges of the application of gamification in universities and colleges. It looks into the pros and cons of the use of gamification in higher education, reviews the application of gaming elements in assessments and suggests that the ...
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Quality Assessment of Traditional Persian Medicine Observational StudiesQuality Assessment of Traditional Persian Medicine Observational Studies

Iranian Journal of Public Health
Background: Although observational studies are valuable sources of scientific evidence, they are prone to bias and confounding. This study aimed to assess the quality of observational studies in Traditional Persian medicine (TPM). Methods: A systematic search was conducted in national and international databases up to the end of 2022 to identify ...
Mojtaba Norouzi, Ali Akbar Haghdoost, Mohammad Setayesh   +2 more
openaire   +3 more sources

Developing a transparent reporting tool for AI-based diagnostic prediction models of disease and syndrome in Chinese medicine: a Delphi protocol

Frontiers in Digital Health
IntroductionThe application of artificial intelligence in diagnostic prediction models for diseases and syndromes in Chinese Medicine (CM) has been rapidly expanding, accompanied by a significant increase in related research publications.
Jieyun Li, Jieyun Li, Wei Song Seetoh, Jiekee Lim, Jiekee Lim, Xin’ang Xiao, Xin’ang Xiao, Kehu Yang, Si Yong Yeo, Boyun Sun, Jinhua Liu, Zhaoxia Xu, Zhaoxia Xu, Linda L. D. Zhong   +13 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source