Results 71 to 80 of about 3,154,939 (307)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Advances in Small-Molecule C-KIT/PDGFRα Inhibitors for the Treatment of Gastrointestinal Stromal Tumors

Pharmaceutical Fronts
Stem cell factor receptor (C-KIT) or platelet-derived growth factor receptor α (PDGFRα) gene mutations have been identified as oncogenic drivers for most gastrointestinal stromal tumors (GISTs).
Xuan Zheng, Hong Liang, Yang Zhou, Xiaoyun Lu   +3 more
doaj   +1 more source

Integrated assessment : new assessment methods literature review [PDF]

, 2004
The assessment of students in higher education performs a number of functions, some of which may not always be compatible with each other. Traditionally, the role of the assessor has involved determining the level of competence displayed in undertaking ...
Crisp, B., Dutton, K., Green Lister, Pam
core  

Facet-sparing lumbar decompression with a minimally invasive flexible MicroBlade Shaver® versus traditional decompression: quantitative radiographic assessment. [PDF]

, 2012
BackgroundLaminectomy/laminotomy and foraminotomy are well established surgical techniques for treatment of symptomatic lumbar spinal stenosis. However, these procedures have significant limitations, including limited access to lateral and foraminal ...
Berven, Sigurd, Block, Jon E, Lauryssen, Carl, Miller, Larry E, Mimran, Ronnie, Sheinberg, Michael, Summa, Christopher   +6 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Exposure assessment of geniposide in Gardenia consuming population

Zhongguo shipin weisheng zazhi
ObjectiveTo understand the situation of Gardenia consumption in Chinese residents and to assess the geniposide exposure level and health risk of the Gardenia consumption population in China.MethodsData on geniposide content in Gardenia jasminoides in ...
QIU Xuejiao, LI Qiang, ZHANG Lei, PAN Feng, LI Jianwen, FAN Penghui, WANG Zhimin, BAO Huihui, QIN Si   +8 more
doaj   +1 more source

Constructing a no-reference H.264/AVC bitstream-based video quality metric using genetic programming-based symbolic regression [PDF]

, 2013
In order to ensure optimal quality of experience toward end users during video streaming, automatic video quality assessment becomes an important field-of-interest to video service providers.
Demeester, Piet, Deschrijver, Dirk, Dhaene, Tom, Staelens, Nicolas, Vermeulen, Brecht, Vladislavleva, E   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Parametric Analysis on the Lateral Force Resistance of Qing Dynasty Timber Frame Containing Stacked Purlins

BioResources, 2023
In ancient wooden structures of the Qing dynasty in China, stacked purlins are important longitudinal elements. In this study, a refined finite element model of a four-column timber frame containing stacked purlins was built.
Yibin Chang, Jian Dai
doaj   +2 more sources

The importance of task appropriateness in computer‐supported collaborative learning [PDF]

, 1999
Collaborative learning activities can be beneficial for exchanging ideas, sharing experiences, and developing shared understanding. It is our view that the task given to the student is central to the success or otherwise of the learning experience.
Buckner, Kathy, Morss, Kate
core   +3 more sources