Results 121 to 130 of about 164,752 (316)
Distributed reinforcement learning for a traffic engineering application [PDF]
Mark D. Pendrith
openalex +1 more source
SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi+11 more
wiley +1 more source
Congestion Control Mechanism for Traffic Engineering within MPLS Networks [PDF]
Felicia Holness, Chris Phillips
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VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang+4 more
wiley +1 more source
Investigation of how the AIE molecules and functionalized AIE nanoparticle impact protein stability, protein homeostasis in cells, biodistribution, and biocompatibility in animal model. Abstract Aggregation‐induced emission (AIE) materials offer promising perspectives in disease diagnosis and therapeutics given their unique optical and photochemical ...
Wang Wan+12 more
wiley +1 more source
Efficient Traffic Engineering in an NFV Enabled IoT System. [PDF]
Nguyen TT, Pham TM.
europepmc +1 more source
Decentralized optimal traffic engineering in the internet [PDF]
Constantino Lagoa, Hao Che
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NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao+18 more
wiley +1 more source
5.1.2 Chances for Systems Engineering in Road Transport and Traffic Telematics [PDF]
J. N. Hadderingh
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This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou+9 more
wiley +1 more source