Results 41 to 50 of about 67,614 (313)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Investigating Pedestrian Crossing Patterns at Crossing Locations Based on Trajectory Data Collected by UAV

Journal of Advanced Transportation, 2023
Previous studies on pedestrian crossing have mostly focused on pedestrian crossing decisions; while as an important behavioral aspect, the pedestrian crossing process, i.e., their motions during the entire crossing process, has been narrowly studied ...
Ting Fu, Shuke Xie, Rubing Li, Junhua Wang, Lanfang Zhang, Anae Sobhani, Shou’en Fang   +6 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Multi-path Traffic Engineering Protocol Based on TeXCP [PDF]

Jisuanji gongcheng, 2018
In order to adapt to the real-time network traffic demand,and find the network fault in time,based on classic online distributed traffic engineering protocol TeXCP,this paper proposes Multi-path Traffic Engineering(MTE) protocol.The protocol consists of ...
YANG Yi,WU Zhaofeng,HU Guyu
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Selektivno letenje i njegove odrednice kao prvi stupanj odabira kandidata za pilotski poziv

Promet (Zagreb), 2012
Flying as the vocational commitment of a person makes one of the most complex aspects of human activity. The beginning of materialization of such professional orientation refers to the selection of candidates for student-pilots at the Faculty of Traffic ...
Josip Njari
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A Modified Latent Dirichlet Allocation Topic Approach for Driving Style Exploration Using Large-Scale Ride-Hailing GPS Data

Journal of Advanced Transportation, 2023
Driving style identification is of vital importance for intelligent driving system design and urban traffic management. This study aims to identify and analyze driving styles using large-scale ride-hailing GPS data taking different time periods, traffic,
Ye Li, Yiqi Chen, Jie Bao, Lu Xing, Jinjun Tang, Changyin Dong, Ruifeng Gu   +6 more
doaj   +1 more source

Internet Traffic Engineering [PDF]

, 2003
Traffic engineering encompasses a set of techniques that can be used to control the flow of traffic in data networks. We discuss several of those techniques that have been developed during the last few years. Some techniques are focused on pure IP networks while others have been designed with emerging technologies for scalable Quality of Service (QoS ...
Bonaventure, Olivier, Trimintzios, Panos, Pavlou, George, Quoitin, Bruno, Azcorra Saloña, Arturo, Bagnulo Braun, Marcelo Gabriel, Fegkas, Paris, García-Martínez, Alberto, Georgatsos, Panos, Georgiadis, Leonidas, Jacquenet, Christian, Swinnen, Louis, Tandel, Sebastien, Uhlig, Steve   +13 more
openaire   +3 more sources