Results 81 to 90 of about 3,731,861 (383)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A Modified Latent Dirichlet Allocation Topic Approach for Driving Style Exploration Using Large-Scale Ride-Hailing GPS Data

Journal of Advanced Transportation, 2023
Driving style identification is of vital importance for intelligent driving system design and urban traffic management. This study aims to identify and analyze driving styles using large-scale ride-hailing GPS data taking different time periods, traffic,
Ye Li, Yiqi Chen, Jie Bao, Lu Xing, Jinjun Tang, Changyin Dong, Ruifeng Gu   +6 more
doaj   +1 more source

Combined Intra- and Inter-domain Traffic Engineering using Hot-Potato Aware Link Weights Optimization [PDF]

, 2008
A well-known approach to intradomain traffic engineering consists in finding the set of link weights that minimizes a network-wide objective function for a given intradomain traffic matrix.
Balon, Simon, Leduc, Guy
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Selektivno letenje i njegove odrednice kao prvi stupanj odabira kandidata za pilotski poziv

Promet (Zagreb), 2012
Flying as the vocational commitment of a person makes one of the most complex aspects of human activity. The beginning of materialization of such professional orientation refers to the selection of candidates for student-pilots at the Faculty of Traffic ...
Josip Njari
doaj   +1 more source

Cooperative Control of Interconnected Air Suspension Based on Energy Consumption Optimization

Shock and Vibration, 2022
In this study, a cooperative control method based on model predictive control and multiagent theory is proposed to control an interconnected air suspension system with three controllable structures of interconnection mode, damping, and vehicle height ...
Guoqing Geng, Shuai Zeng, Liqin Sun, Zhongxing Li, Wenhao Yu   +4 more
doaj   +1 more source

Leveraging Personal Navigation Assistant Systems Using Automated Social Media Traffic Reporting

, 2020
Modern urbanization is demanding smarter technologies to improve a variety of applications in intelligent transportation systems to relieve the increasing amount of vehicular traffic congestion and incidents.
Ghazzai, Hakim, Massoud, Yehia, Wan, Xiangpeng   +2 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The Impact of Uncertainty on Pedestrians’ Decision to Start Roadway Crossing during the Clearance Phase

Complexity, 2021
Clearance phase at signalized crosswalks is an important parameter of pedestrians’ safety because it helps them to complete the crossing before the green signal for vehicles.
Milan Simeunović, Andrijana Jović, Pavle Pitka, Mladen Dobrić   +3 more
doaj   +1 more source