Results 51 to 60 of about 395,211 (318)

Targeting of keloid with TRAIL and TRAIL-R2/DR5

Journal of Dermatological Treatment, 2020
Keloid is a common and frequently-occurring disease in plastic surgery, and its ugly appearance and itching symptoms bring mental and life pain to patients. However, the clinical treatment of keloid, such as drug injection treatment, surgical resection, cryotherapy, laser treatment and other therapeutic effects are poor.
Pengfei, Sun, Zhensheng, Hu, Bo, Pan, Xiaosheng, Lu   +3 more
openaire   +2 more sources

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth

, 2009
Background: Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to ...
Amy Prosser, Robinson, B.W.S., Currie, A.J., Scalzo, A.A., Joanne Salmons, Robbert G van der Most, Mark J Smyth, Bruce W S Robinson, Salmons, J., Lake, R.A., Smyth Mark J., Andrew J Currie, Amanda L Cleaver, Prosser, Amy, van der Most, R.G., Degli-Esposti, M.A., Salmons, Joanne, Lake, Richard A., Prosser, A., Prosser Amy, Nowak, A.K., Currie, Andrew J., van der Most Robbert G., Smyth, M.J., Robinson Bruce W. S., Lake Richard A., Degli-Esposti, Mariapia A., Scalzo Anthony A., Currie Andrew J., Nowak, Anna K., Sathish Mahendran, Cleaver, Amanda L., Richard A Lake, Nowak Anna K., van der Most, Robbert G., Larma, I., Mahendran, S., Anna K Nowak, Degli-Esposti Mariapia A., Anthony A Scalzo, Cleaver, A.L., Robinson, Bruce W.S., Larma, Irma, Irma Larma, Cleaver Amanda L., Smyth, Mark J., Larma Irma, Mehendran, Sathish, Scalzo, Anthony A., Salmons Joanne, Mahendran Sathish, Mariapia A Degli-Esposti   +51 more
core   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Dynamics of the left ventricular ejection fraction after revascularization in patients with heart failure with preserved ejection fraction, association with the TRAIL protein [PDF]

Терапевтический архив
Aim. To study the association of dynamics of the ejection fraction (EF) of the left ventricle (LV) with the development of adverse cardiovascular events within 12 months after revascularization in patients with chronic heart failure with preserved LV EF (
Elena A. Kuzheleva, Alla A. Garganeeva, Olga V. Tukish, Karina N. Vitt, Mikhail Iu. Kondratiev, Mikhail V. Soldatenko   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Permafrost characterization, mapping, modelling, and knowledge sharing in support of construction of community roads and trails over sensitive tundra. Kugluktuk, Nunavut, Canada

Arctic Science
As part of an Inuit-led initiative, a collaborative research project combined scientific methods and Inuit knowledge to design an environmentally friendly and climate change-resilient access route from the community of Kugluktuk to Kugluk Territorial ...
Michel Allard, Stephanie Coulombe, Marc-André Ducharme, Samuel Bilodeau, Larry Adjun, Leesee Papatsie, Gerry Attatahak, Samuel Gagnon   +7 more
doaj   +1 more source

An increase of the region's competitiveness through effective tourist product management: an example using the thematic trail

Humanities and Social Sciences, 2020
The present article explores the possibility of increasing the competitiveness of regions by creating interesting tourist products that are based on local resources. An example of such a regional tourist product is the thematic (or ‘nature’) trail.
Anna Nizioł, Norbert Życzyński
doaj   +1 more source

The information trail

eLife, 2016
The ability of a wild baboon to acquire and exploit social information depends on its individual characteristics and its position within various social networks.
openaire   +3 more sources

On the campaign trail [PDF]

BMJ, 1983
One of the aspects of a general election campaign that the voters never see is the way that a party leader's speech grows and grows in performance. The point is that the actual audience at each rally hears basically the same speech, but with sections added to highlight the issue of the day.
openaire   +2 more sources