Results 61 to 70 of about 395,211 (318)

Old Oregon Trail from the Missouri to the Pacific

, 1943
Relief shown pictoriallyShows the Old Oregon Trail, Mormon Trail, Lewis and Clark's route, Applegate Trail, Naches Pass Trail, Barlow Road, and Fremont's routeIncludes pictorial representations of landmarks, animals, and peopleThis archived document is ...

core  

Mormon Trail, The

, 1996
Part history, part resource book, part guide, and part photographic essay, The Mormon Trail Yesterday and Today is an essential reference for readers of all ages who are interested in the Mormon trek west.
Hill, William E., William E. Hill, Hill, William   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Differential white blood cell count and epigenetic clocks: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Human aging and white blood cell (WBC) count are complex traits influenced by multiple genetic factors. Predictors of chronological age have been developed using epigenetic clocks.
Manli Sun, Huan Yang, Yang Hu, Jiaqi Fan, Mingjing Duan, Jingqi Ruan, Shichang Li, Yang Xu, Yue Han   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Pedological aspects as environmental quality indicators of a touristic trail in the Serra do Cipó National Park/MG

REM: International Engineering Journal
Soil provides important support for anthropogenic activities, and earthen trails, which have always been present in the natural landscape, are routes of access to various tourist attractions. In recent decades, trails have been widely used as a method of
Ricardo Eustáquio Fonseca Filho, Angélica Fortes Drummond Chicarino Varajão, Múcio do Amaral Figueiredo, Paulo de Tarso Amorim Castro   +3 more
doaj   +1 more source

La promoción del turismo rural a través del "trail running": el caso de Carrícola en la comarca de "La Vall d'Albaida"

PASOS Revista de Turismo y Patrimonio Cultural, 2017
El running se ha convertido en poco tiempo en un deporte de masas, generando todo un negocio a su alrededor y un impacto económico importante en aquellas localidades que albergan este tipo de eventos.
FEDERICO SOLER VAYÁ, ENRIQUE SAN MARTÍN GONZÁLEZ   +1 more
doaj   +1 more source

Appalachian Trail 1981

, 1981
"March 1981."; Cover title of accompanying text: Comprehensive plan.; Spine title of accompanying text: Appalachian Trail comprehensive plan.; "Source Data: Map base is Geological Survey 1:2,500,000 scale map, dated 1972."; Accompanied by text ...

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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Feeding trails of Dugong Dugong dugon (Müller, 1776) (Mammalia: Sirenia: Dugongidae) in the Gulf of Kachchh, western coast of India

Journal of Threatened Taxa, 2019
Dugong Dugong dugon (Müller, 1776) is the only herbivorous marine mammal distributed along the tropical and subtropical oceans of the Indo-Pacific regions.
Deepak Apte, Dishannt Parasharya, Bhavik Patel   +2 more
doaj   +1 more source