Results 51 to 60 of about 3,499,518 (292)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

SIMULATION OF EMBOLIZATION PARTICLE TRAJECTORIES

Frontiers in Heat and Mass Transfer, 2011
A numerical simulation has been performed on the hemodynamics associated with embolization procedures. The flow geometry includes a multibranch artery which is upstream of a targeted tumor. During the procedure, drug-eluting particles are released into the local arterial geometry and are carried downstream by the flowing blood.
John Abraham, Nessa Johnson, Zach Helgeson, Michael Hennessey   +3 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Toxicity Profiling Validates Trajectory Modeling for Identifying Sogatella furcifera Migration Sources in Southern China

Insects
Sogatella furcifera (Horváth) is a major migratory rice pest, yet accurate source attribution for this insect remains a persistent challenge. To assess the accuracy of trajectory modeling in determining the source areas of S.
Jian Zhu, Pengqi Quan, Yan Wu, Chao Li, Mingyong Ma   +4 more
doaj   +1 more source

On simulating and predicting pedestrian trajectories in a crowd

, 2020
Crowds of people are gathering at multiple venues, such as concerts, political rallies, as well as in commercial malls, or just simply walking on the streets. More and more people are flocking to live in urban areas, thus generating a lot of scenarios of crowds.
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Motion error estimation of circular arc interpolation cutter path of machining center produced by NC linear acceleration/deceleration processing

Nihon Kikai Gakkai ronbunshu
From the machining center (MC) user’s point of view, this paper, as the second report of a systematic study, proposes a practical approach to estimate the trajectory error of a circular arc interpolation cutter path produced by the NC linear acceleration/
Hua QIU, Tetsurou YAMAGUCHI
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Trajectory based video analysis in multi-camera setups [PDF]

, 2010
PhDThis thesis presents an automated framework for activity analysis in multi-camera setups. We start with the calibration of cameras particularly without overlapping views.
Anjum, Nadeem
core   +2 more sources

Comparative Analysis of Large-Scale Testing and Three-Dimensional Rockfall Modeling in Assessment of Tabulated Coefficients of Restitution

Applied Sciences
Rockfall hazard assessment and mitigation design relies heavily on three-dimensional trajectory modeling, in which the coefficient of restitution (COR) is a governing parameter controlling rebound, energy dissipation, and runout distance.
Grant Goertzen, Kinley Seabaugh, Nick Hudyma   +2 more
doaj   +1 more source