Results 141 to 150 of about 37,856 (275)
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Girmay Fitiwi Lema,1 Endale Gebreegziabher Gebremedhn,1 Amare Hailekiros Gebregzi,1 Yilkal Tadesse Desta,1 Adugna Aregawi Kassa2 1Department of Anesthesia, School of Medicine, University of Gondar, Gondar, 2Department of Anesthesia, School of Medicine ...
Gebremedhn EG +4 more
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Tramadol – vet pharmaceutical placebo? [PDF]
Tramadol är en centralt verkande opioid vars smärtlindrande effekt främst anses bero av två mekanismer. Dels en svag affinitet för μ-receptorn men även en inhiberande effekt på återupptaget av och en stimulerande effekt på den cellulära frisättningen av ...
Josefsson, Malin
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ABSTRACT Objective To evaluate the association between prenatal exposure to opioids analgesics and academic performance in third grade children. Design Population‐based cohort study using linked data from New South Wales birth records, medicine dispensing data, and national standardised test results.
Bianca Varney +7 more
wiley +1 more source
Regional perspectives: Substance use related problems in Ethiopia
Abstract Ethiopia, with a population exceeding 130 million, presents a complex landscape for understanding substance use disorders. The country's diverse cultural heritage, varying regional practices, and evolving socioeconomic conditions create unique factors of substance use that differ markedly from global trends.
Tesfa M. Yimer +4 more
wiley +1 more source
ABSTRACT Introduction We have been funded to examine post‐incarceration health and social outcomes for all people incarcerated in New South Wales, Australia, 2000–2022; assess treatment and services for drug dependence and serious mental illness; and project the impact of expanding intervention coverage. We will use a linked cohort, the Prison Outcomes
Louisa Degenhardt +19 more
wiley +1 more source
Ovarian hormones and high‐fat diet duration distinctively modulate hypothalamic chemokine profile
Abstract Excessive intake of saturated fats triggers inflammation in the hypothalamus, a key regulator of energy balance. In the chronic phase of this inflammatory response, bone marrow‐derived and lymphoid cells are chemoattracted to this region, partially mitigating high‐fat diet (HFD)‐induced metabolic impairments.
Alexia Guimaraes Batista Augusto +8 more
wiley +1 more source
The raphe nuclear organization and serotonergic system in the bat (Artibeus planirostris)
Schematic representation of the methodological workflow used to characterize the serotonergic (5‐HT) system in the bat Artibeus planirostris. Serotonin (5‐HT) immunohistochemistry was performed on brainstem sections to identify and map the distribution of serotonergic neurons within the raphe nuclei.
Mariana D. Leite +9 more
wiley +1 more source
Tramadol and Sexual Dysfunction
Hai Err, Viroj Wiwanitkit
openaire +4 more sources
Bu çalışmada, postoperatif ağrı kontrolünde, epidural yolla uygulanan tramadol, tramadol-droperidol ve tramadol-klonidin kombinasyonlarının, etkinlik ve yan etki açısından karşılaştırılmaları amaçlandı.
Tomatır, Erkan +3 more
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