Results 151 to 160 of about 68,585 (257)

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

Review of Structural Modification and Development of Novel Tramadol Derivatives. [PDF]

Molecules
Wang N, Zhou X, Wang J, Sun L, Liu B, Yin L.   +5 more
europepmc   +1 more source

Development and Internal Validation of a Machine Learning Model for Predicting Long‐Term Opioid Therapy After Hip Fracture Surgery in Older, Opioid‐Naïve Adults

European Journal of Pain, Volume 30, Issue 5, May 2026.
ABSTRACT Background Long‐term opioid therapy (LTOT) after hip fracture surgery is a common postoperative complication associated with adverse outcomes, yet tools to identify at‐risk patients among opioid‐naïve older adults are lacking. This study aimed to develop and internally validate a parsimonious model to predict LTOT following hip fracture ...
Yasmina Maria Tudorache, Simon Storgaard Jensen, Katie Jane Sheehan, Jan‐Erik Gjertsen, Alma Becic Pedersen   +4 more
wiley   +1 more source

Medial parapatellar surgical approach leads to greater loss of postural sway complexity compared to mid‐vastus approach in women undergoing total knee arthroplasty

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 5, Page 1700-1712, May 2026.
Abstract Purpose Total knee arthroplasty (TKA) is associated with acute postoperative effects that increase the risk of falls. These effects differ between the medial parapatellar (PP) and mid‐vastus (MV) surgical techniques but have not been evaluated in terms of postural sway complexity.
Vasileios Mylonas, Stylianos Grigoriadis, Dimitris Metaxiotis, Eleftherios Kellis, Nick Stergiou, Thomas Nikodelis   +5 more
wiley   +1 more source

Lack of Effectiveness of Tramadol for Earlier Limb Weight-Bearing After Femoral Head and Neck Excision in 38 Dogs. [PDF]

Animals (Basel)
Krystalli A, Kazakos GM, Savvas I, Prassinos NN.   +3 more
europepmc   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Exercise Training Ameliorates The Tramadol-Induced Toxicity on VEGF/VEGFRs/PI3K/AKT Signaling Pathway in Testicular Tissue after Tramadol Withdrawal. [PDF]

Int J Fertil Steril
Saeidifard V, Tofighi A, Tolouei Azar J, Razi M.   +3 more
europepmc   +1 more source

Inpatient Opioid Use in Head and Neck Microvascular Free Flap Reconstruction

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1230-1235, May 2026.
Abstract Objectives The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary aims include evaluating the impact of a multimodal analgesia (MMA) protocol and COVID‐19 visitor ...
Patricia Timothee, Alessandra Bliss, Daniel Blumenthal, John Dowd, Emily Clementi, Bruce Davidson, Michael Reilly, Matthew Pierce, Jonathan Giurintano   +8 more
wiley   +1 more source

Impact of the Raqeeb narcotic controlling system on tramadol prescriptions in surgical patients: A pre-post implementation study. [PDF]

Saudi J Anaesth
Almarhabi Y.
europepmc   +1 more source

Surgical management of an open humeral fracture in a greater rhea (Rhea americana): Internal placement of a locking compression plate and post‐operative complications

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
SUMMARY A 17‐year‐old, 24‐kg, female greater rhea (Rhea americana) presented with an acute onset of left wing droop. Clinical examination and radiographs revealed an open, simple, displaced, short‐oblique diaphyseal fracture of the distal third of the left humerus.
Pierre Huberdeau, Thomas Coutant, Aram Arslanian, Emeline Maurice, Fouad Stephan, Sylvie Laidebeure, Alexis Lécu   +6 more
wiley   +1 more source