Results 161 to 170 of about 13,664 (199)
, 2001 The metabolism of cis-tramadol has been studied in human liver microsomes and in cDNA-expressed human cytochrome P-450 (CYP) isoforms. Human liver microsomes catalyzed the NADPH-dependent metabolism of tramadol to the two primary tramadol metabolites ...
Tonelli, A.P. +6 more
core
Drugs, 1994 (+/-)-Tramadol is a central analgesic with low affinity for opioid receptors. The rate of production of its M1 metabolite (O-demethyl tramadol) is influenced by debrisoquine-type polymorphism, and this metabolite shows a higher affinity for opioid receptors than the parent drug.
Jules Desmeules, Pierre Dayer, P Dayer
exaly +5 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Drugs, 2003
The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.
Karen, McClellan, Lesley J, Scott
openaire +2 more sources
The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.
Karen, McClellan, Lesley J, Scott
openaire +2 more sources
The Pharmacogenetics of Tramadol
Clinical Pharmacokinetics, 2015Tramadol hydrochloride is used worldwide as an analgesic drug with a unique dual function. The metabolic enzymes cytochrome P450 (CYP) 3A4, CYP2B6, and CYP2D6 and the various transporters [adenosine triphosphate-binding cassette B1/multidrug resistance 1/P-glycoprotein, organic cation transporter 1, serotonin transporter (SERT), norepinephrine ...
Dorte Lassen, Per Damkier, Kim Brøsen
openaire +2 more sources
Cochrane Database of Systematic Reviews, 2005
Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of ...
M S, Cepeda +3 more
openaire +2 more sources
Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of ...
M S, Cepeda +3 more
openaire +2 more sources
Current Opinion in Anaesthesiology, 2000
Tramadol is a unique analgesic offering moderate, dose-related pain relief through its action at multiple sites. In contrast to pure opioid agonists, it has a low risk of respiratory depression, tolerance and dependence. Troublesome side-effects have been reported, but tramadol has been established as an adjunct to non-steroidal anti-inflammatory drugs
P J, le Roux, J F, Coetzee
openaire +2 more sources
Tramadol is a unique analgesic offering moderate, dose-related pain relief through its action at multiple sites. In contrast to pure opioid agonists, it has a low risk of respiratory depression, tolerance and dependence. Troublesome side-effects have been reported, but tramadol has been established as an adjunct to non-steroidal anti-inflammatory drugs
P J, le Roux, J F, Coetzee
openaire +2 more sources
2013
A profile of the analgesic tramadol hydrochloride ((1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride) is provided in this chapter and includes a summary of the physical characteristics known for this drug substance (e.g., UV/vis, IR, NMR, and mass spectra). Details regarding the stability of tramadol hydrochloride in the
Robert, Smyj +2 more
openaire +2 more sources
A profile of the analgesic tramadol hydrochloride ((1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride) is provided in this chapter and includes a summary of the physical characteristics known for this drug substance (e.g., UV/vis, IR, NMR, and mass spectra). Details regarding the stability of tramadol hydrochloride in the
Robert, Smyj +2 more
openaire +2 more sources
European journal of pain (London, England), 2000
Tramadol is an option for the treatment of rheumatological pain. Its mode of action and safety profile distinguishes it from other opioids. Tramadol differs from other opioids by combining a weak opioid and a monoaminergic mode of action. It is effective in different types of moderate-to-severe pain, including neuropathic pain. Moreover, as the mode of
openaire +2 more sources
Tramadol is an option for the treatment of rheumatological pain. Its mode of action and safety profile distinguishes it from other opioids. Tramadol differs from other opioids by combining a weak opioid and a monoaminergic mode of action. It is effective in different types of moderate-to-severe pain, including neuropathic pain. Moreover, as the mode of
openaire +2 more sources
Douleur et Analgésie, 1997
Lors d'une etude randomisee effectuee en double aveugle, 35 patientes de classe ASA I et II recoivent une dose de charge de 150 mg de tramadol par voie intraveineuse, suivie dans le premier groupe d'une infusion de tramadol a 15 mg/heure ou dans le deuxieme groupe d'une perfusion de solution saline.
openaire +1 more source
Lors d'une etude randomisee effectuee en double aveugle, 35 patientes de classe ASA I et II recoivent une dose de charge de 150 mg de tramadol par voie intraveineuse, suivie dans le premier groupe d'une infusion de tramadol a 15 mg/heure ou dans le deuxieme groupe d'une perfusion de solution saline.
openaire +1 more source