Results 21 to 30 of about 94,263 (328)

Clinical pharmacology of tramadol and tapentadol, and their therapeutic efficacy in different models of acute and chronic pain in dogs and cats

open access: yesJournal of Advanced Veterinary and Animal Research, 2021
Opioids are considered the gold standard to manage acute or chronic or mild to severe pain. Tramadol is a widely prescribed analgesic drug for dogs and cats; it has a synthetic partial agonism on μ-opioid receptors and inhibits the reuptake of ...
A. Domínguez-Oliva   +3 more
semanticscholar   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

open access: yesHepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman   +4 more
wiley   +1 more source

Factors Associated with Tramadol Abuse: A Cross-Sectional Study Among Commercial Drivers and Assistants in the Accra Metropolitan Area of Ghana

open access: yesDrugs - Real World Outcomes, 2021
There is increasing public health concern regarding the addiction and dependence potential of tramadol. This study sought to determine factors associated with tramadol abuse among commercial drivers and assistants in the Accra Metropolitan Area of Ghana.
Mavis Danso, F. Anto
semanticscholar   +1 more source

Identification for antitumor effects of tramadol in a xenograft mouse model using orthotopic breast cancer cells

open access: yesScientific Reports, 2021
In our previous research showed that tramadol having potential anti-tumor effect was associated with enhancement of oncological prognosis in patients with breast cancer surgery.
M. Kim   +8 more
semanticscholar   +1 more source

The effect of orexin-2 and endocannabinoid-1 antagonists on neuronal activity of hippocampal CA1 pyramidal neurons in response to tramadol in rats

open access: yesAdvanced Biomedical Research, 2022
Background: CA1, as a major structure involved in learning and memory, has been shown to be affected by tramadol addiction. Both orexin and endocannabinoid receptors express in CA1 and play an important role in drug dependency.
Vajihe Imanpour, Parham Reisi
doaj   +1 more source

The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study

open access: yesThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Background Arterial hypertension, cigarette smoking, excessive alcohol abuse and drug addiction such as cocaine all are known risk factors for aneurysmal subarachnoid hemorrhage (SAH).
Ahmed Elbassiony   +7 more
doaj   +1 more source

Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis

open access: yesJournal of the American Medical Association (JAMA), 2019
Importance An American Academy of Orthopaedic Surgeons guideline recommends tramadol for patients with knee osteoarthritis, and an American College of Rheumatology guideline conditionally recommends tramadol as first-line therapy for patients with knee ...
C. Zeng   +7 more
semanticscholar   +1 more source

Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep [PDF]

open access: yes, 2015
Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of
A., Di Salvo   +6 more
core   +1 more source

Determination of Tramadol in human plasma by HPLC with fluorescence detection [PDF]

open access: yes, 2016
Tramadol is a centrally acting analgesic, atypical opioid, and although it is generally considered as a medicinal drug with a low potential for dependence, there is growing evidence of tramadol abuse in some countries.
Abdul Jalil Ebrahim, Zainab   +4 more
core   +3 more sources

Perbandingan Intensitas Nyeri dan Kadar Prostaglandin Kombinasi Tramadol dan Deksketoprofen dengan Tramadol dan Parasetamol Intravena pada Pasien Bedah Ortopedi Ekstremitas Bawah

open access: yesJurnal Anestesi Perioperatif, 2019
Analgesia multimodal adalah prinsip manajemen nyeri pascaoperasi. Penelitian ini merupakan uji klinis rancangan acak tersamar ganda. Tujuan penelitian ini membandingkan efek kombinasi analgesik tramadol dan deksketoprofen dengan tramadol dan parasetamol ...
Clara Valentia Josephine   +3 more
doaj   +1 more source

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