Results 141 to 150 of about 675,014 (180)

trans‐Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability

European Journal of Pharmacology, 2019
Leishmania parasites infect macrophages causing a wide spectrum of human diseases encompassing from cutaneous to visceral forms. The drugs currently used in leishmaniasis treatment are highly toxic and associated with acquired resistance. Seeking novel therapeutic targets, we conducted a comprehensive in vitro study to investigate the action of trans ...
M. M. Miranda-Sapla, Fernanda Tomiotto-Pellissier, J. P. Assolini, A. Carloto, Bruna Taciane da Silva Bortoleti, M. D. Gonçalves, E. R. Tavares, Jean Henrique da Silva Rodrigues, A. Simão, L. Yamauchi, C. Nakamura, W. A. Verri, I. N. Costa, I. Conchon-Costa, W. Pavanelli   +14 more
semanticscholar   +4 more sources

Two Nitro-α-methoxy-trans-chalcones [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 1996
The crystal structures of 2-methoxy-3-(3-nitrophenyl)-1-phenylprop-2-en-1-one, C16H13NO4, (Ia), and 2-methoxy-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one, C16H13NO4, (Ib), are reported. These two molecules are constitutional isomers differing in the position of the nitro group attached to one of the phenyl rings.
H. J. Bader, G. Schütz, M. Bolte
openaire   +1 more source

Anti-angiogenic Potential of Trans-chalcone in an In Vivo Chick Chorioallantoic Membrane Model: An ATP Antagonist to VEGFR with Predicted Blood-brain Barrier Permeability.

Cardiovascular & Hematological Agents in Medicinal Chemistry, 2023
BACKGROUND Glioblastoma multiforme (GBM) is characterized by massive tumorinduced angiogenesis aiding tumorigenesis. Vascular endothelial growth factor A (VEGF-A) via VEGF receptor 2 (VEGFR-2) constitutes majorly to drive this process.
Anna Senrung, Tanya Tripathi, N. Aggarwal, Divya Janjua, Arun Chhokar, Joni Yadav, A. Chaudhary, Kulbhushan Thakur, Tejveer Singh, A. Bharti   +9 more
semanticscholar   +1 more source

Clay-catalysed solventless synthesis of trans-chalcones

Green Chemistry, 2001
trans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.
Ballini R., Bosica G., Maggi R., Ricciutelli M., Righi P., Sartori G., Sartorio R.   +6 more
openaire   +3 more sources

Polycaprolactone/epoxide-functionalized silica composite microparticles for long-term controlled release of trans-chalcone

Journal of polymer engineering, 2022
In this study, controlled release of trans-chalcone was achieved by using a polycaprolactone-based hybrid system as the drug carrier material. Encapsulation efficiency was obtained in the range of 70–75% for various formulations and in vitro release ...
Y. Kaptan, Y. Güvenilir
semanticscholar   +1 more source

Circular dichroism spectra of trans-chalcone epoxides

Tetrahedron: Asymmetry, 2007
Abstract The electronic absorption and CD spectra of (−)- trans -chalcone epoxide and its derivatives with methyl and alkoxy substituents at the ortho -positions of the aromatic rings have been measured. The spectra have been assigned with help of the energies, oscillatory strengths, and rotatory strengths of the singlet transitions obtained from ...
Péter Bakó, Attila Makó, Miklós Kubinyi, Miklós Kubinyi, Krisztina Pál, Mihály Kállay   +5 more
openaire   +2 more sources

Abstract 4654: Antitumorigenic activity of trans-chalcone in osteosarcoma

Cancer Research, 2015
Abstract Background and Aims: Osteosarcoma is the most common bone cancer, and it affects mostly teenagers and children. Although the emergence of multidrug therapies has improved available treatments for osteosarcoma, approximately 30% of patients will still develop metastasis.
Seung Joon Baek, Ana Lúcia Fachin, Gabriel da Silva, Mozart Marins   +3 more
openaire   +2 more sources

Electronic absorption spectra of heterocyclic analogs of trans-chalcone

Chemistry of Heterocyclic Compounds, 1977
Thiophene, furan, and pyrrole analogs of trans-chalcone have UV spectra consisting of bands belonging to the spectra of the corresponding 2-acetylhetaryls and 2-hetarylideneacetones that are shifted bathochromically as a result of mutual perturbation of these two crossconjugated fragments.
A. Raushal, A. A. Sukhorukov, M. Reinkhardt, V. F. Lavrushin   +3 more
openaire   +2 more sources

Chemical sensing of chalcones by voltammetry: trans-Chalcone, cardamonin and xanthohumol

Electrochimica Acta, 2013
Abstract Xanthohumol (XN) and cardamonin (CD) belong to the chemical class of chalcones which are phenolic compounds of large interest due to their health promoting properties. In the present work, their electrochemical behavior on a hanging mercury drop electrode (HMDE) is compared to trans -chalcone by means of cyclic voltammetry (CV).
Tavares, E.M., Carvalho, A.M., Gonçalves, Luis M., Valente, I.M., Moreira, M.M., Guido, L.F., Rodrigues, J.A., Doneux, Thomas, Barros, Aquiles   +8 more
openaire   +2 more sources

Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina

Experimental Eye Research, 2011
Retinal neovascularization (RNV) is a critical pathological event and a major cause of blindness. Vascular inflammation and oxidative stress have been shown to play a key role in the induction and progression of RNV. Trans-Chalcone-derived flavonoids have been previously shown to be negative modulators of oxidative stress and inflammatory responses as ...
Annalisa Montemari, Giovanni Parisi, Monica Varano, Manuela Bartoli, M. Labazi, Folami Lamoke   +5 more
openaire   +3 more sources