Results 151 to 160 of about 675,014 (180)

Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase

Molecular Biology Reports, 2010
Trans-chalcone (1,3-diphenyl-2-propen-1-one), a biphenolic core structure of flavonoids precursor was tested for inhibitory activity toward alpha-amylase. Porcine pancreatic alpha-amylase was observed to be effectively inhibited by this compound, which showed competitive behavior with a K(i) of 48 μM. Soluble starch (the natural substrate of the enzyme)
Parichehreh Yaghmaei, Bagher Larijani, Azadeh Ebrahim-Habibi, Mahmoud Najafian, Kazem Parivar, Nastaran Hezareh   +5 more
openaire   +3 more sources

Catalytic Asymmetric Transfer Hydrogenation of trans-Chalcone Derivatives Using BINOL-derived Boro-phosphates.

Organic Letters, 2020
Chiral phosphoric-acid-catalyzed asymmetric reductions of trans-chalcones have been investigated in this work. A BINOL-derived boro-phosphate-catalyzed asymmetric transfer hydrogenation of the carbon-carbon double bond of trans-chalcone derivatives ...
Fei Na, S. López, Alice Beauseigneur, Lucas W. Hernandez, Zhuoxin Sun, J. Antilla   +5 more
semanticscholar   +1 more source

Research on the effects of L-carnitine and trans-chalcone on endoplasmic reticulum stress and oxidative stress in high-fructose corn syrup-fed rats

, 2020
Purpose The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. The deterioration of endoplasmic reticulum (ER) homeostasis is called ER stress.
V. Unsal, K. Deveci, Z. Özmen, M. Tumer
semanticscholar   +1 more source

trans-Chalcone inhibits transforming growth factor-β1 and connective tissue growth factor-dependent collagen expression in the heart of high-fat diet-fed rats

Archives of Physiology and Biochemistry, 2020
Objective: Non-alcoholic fatty liver disease (NAFLD) is one of the main risk factors for cardiovascular mortality and morbidity. This study, for the first time, explored the effects of trans-chalcone on cardiac expressions of myocardial fibrosis-related ...
Elham Karimi-Sales, S. Jeddi, M. Alipour
semanticscholar   +1 more source

New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis

Acta Tropica, 2006
The present study was designed to investigate a new administration model and the antileishmanial activity of a semi-synthetic chalcone, benzylideneacetophenone (trans-chalcone). The antileishmanial activity of this product was first tested in vitro against promastigotes of L. braziliensis, L. tropica, L. infantum and L. amazonensis.
José E. Piñero, Leonor L. Leon, Basilio Valladares, Rosane Maria Temporal, Alexis Oliva, Ignacio A. Jiménez, Isabel L. Bazzocchi, Antônio José da Silva-Gonçalves, Antonio Perera   +8 more
openaire   +3 more sources

Combination of baicalein and trans‐chalcone synergistically reduces amyloid beta and its toxicity in yeast

Alzheimer's & Dementia, 2021
There has been a long quest to uncover effective therapeutic strategy to prevent or cure AD as current strategies only support as palliative care. This study utilizes unmodified and genetically modified Saccharomyces cerevisiae as model organisms to ...
Sudip Dhakal, I. Macreadie, B. Adhikari, P. Ramsland   +3 more
semanticscholar   +1 more source

Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing

The Journal of Supercritical Fluids, 2009
Abstract This work studies the possibility of enhancing the solubility of 1,3-diphenyl-2-propenone, the core structure of chalcones, through lipidic formulations under supercritical CO 2 processing. Microparticles of chalcone, alone and with lipid carriers, were produced by PGSS ® , a method which involves the quick depressurization of a gas ...
Ana Luísa Simplício, Rodrigo Marques da Silva, Sergei G. Kazarian, Catarina M.M. Duarte, Feng H. Tay, A.R. Sampaio de Sousa   +5 more
openaire   +2 more sources

trans-Chalcone prevents insulin resistance and hepatic inflammation and also promotes hepatic cholesterol efflux in high-fat diet-fed rats: modulation of miR-34a-, miR-451-, and miR-33a-related pathways.

Food & Function, 2018
Insulin resistance and inflammation are strongly linked to non-alcoholic fatty liver disease (NAFLD) as a feature of the metabolic syndrome. Furthermore, the role of dysregulation of miR-34a, miR-451, and miR-33a in pathogenesis and progression of NAFLD ...
Elham Karimi-Sales, S. Jeddi, Abbas Ebrahimi-kalan, M. Alipour   +3 more
semanticscholar   +1 more source

Hepatoprotective effect of trans-Chalcone on experimentally induced hepatic injury in rats: inhibition of hepatic inflammation and fibrosis.

Canadian Journal of Physiology and Pharmacology, 2016
The current study investigated the hepatoprotective effect of trans-Chalcone in carbon tetrachloride (CCl4) and paracetamol (PCM) induced liver damage in rats.
Harsimran Singh, S. Sidhu, K. Chopra, M. U. Khan   +3 more
semanticscholar   +1 more source

Hiding and unveiling trans-chalcone in a constrained derivative of 4′,7-dihydroxyflavylium in water: a versatile photochromic system

Organic & Biomolecular Chemistry, 2017
Rigidifying 4′,7-dihydroxyflavylium prevents the formation of trans-chalcone (Ct). The addition of CTAB micelles unveils Ct enabling photochromism. Disrupting the micelles with α-cyclodextrin returns the system to its initial state.
César A. T. Laia, Márcia Pessêgo, João C. Lima, A. Jorge Parola, Fernando Pina, Nuno Basílio, Sandra Gago   +6 more
openaire   +3 more sources