Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice [PDF]
Frontiers in Pharmacology, 2018 Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients.
Larissa Staurengo-Ferrari +12 more
doaj +8 more sources
Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood.
Elham Karimi Sales +3 more
doaj +6 more sources
Hepatoprotective and antifibrotic effects of trans-chalcone against bile duct ligation-induced liver fibrosis in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Several lines of research have shown that hepatic fibrosis is one of the leading causes of death worldwide. Trans-chalcone is a flavonoid precursor with anti-oxidant and anti-inflammatory effects.
Faezeh Javadi +5 more
doaj +6 more sources
Exploring the Therapeutic Potential of trans-Chalcone: Modulation of MicroRNAs Linked to Breast Cancer Progression in MCF-7 Cells [PDF]
International Journal of Molecular Sciences, 2023 Breast cancer is responsible for 25% of all cancers that affect women. Due to its high heterogeneity pattern in clinical diagnosis and its molecular profile differences, researchers have been seeking new targets and therapies, with more specificity and fewer side effects.
Tatiana Takahasi Komoto +2 more
exaly +5 more sources
Effect of silibinin and trans-chalcone in an Alzheimer's disease-like model generated by insulin amyloids [PDF]
Brazilian Journal of Medical and Biological Research, 2023 Amyloid fibrils are characteristic of several disorders including Alzheimer's disease (AD), with no cure or preventive therapy. Diminishing amyloid deposits using aromatic compounds is an interesting approach toward AD treatment.
M. Omidi-Shahsavandi +3 more
doaj +4 more sources
The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria. [PDF]
PLoS Neglected Tropical Diseases, 2019 BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The search for a new chemotherapy against Babesia and Theileria parasites has become increasingly urgent due to the toxic side effects of and developed resistance
Gaber El-Saber Batiha +6 more
doaj +7 more sources
Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition. [PDF]
PLoS ONE, 2018 Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-
Gabriel Silva +13 more
doaj +5 more sources
In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma [PDF]
BMC Cancer, 2023 Background Angiogenesis is an important hallmark of Glioblastoma (GBM) marked by elevated vascular endothelial growth factor-A (VEGF-A) and its receptor 2 (VEGFR-2).
Anna Senrung +9 more
doaj +4 more sources
Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats [PDF]
Endocrine Regulations, 2018 Objective. Trans-chalcone is a chalcone with hepatoprotective and anti-inflammatory effects. However, the mechanism of these positive effects, especially on miR-451 as an inflammatory regulator, is poorly understood. In this regard, this microRNA (miRNA)
Karimi-Sales Elham +4 more
doaj +5 more sources
Exploring the therapeutic potential and chemical properties of trans-chalcone: a comprehensive review [PDF]
Future Medicinal ChemistryAim: Trans-chalcone has emerged as a promising candidate for new therapeutic alternatives, owing to its pharmacological properties and potential in various medical areas. This study aimed to conduct a systematic review of articles, patents and clinical trials on trans-chalcone's applications and biological activities.Areas covered: The review proposed ...
Paula dos Passos Menezes +2 more
exaly +5 more sources