Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats [PDF]
Endocrine Regulations, 2018 Objective. Trans-chalcone is a chalcone with hepatoprotective and anti-inflammatory effects. However, the mechanism of these positive effects, especially on miR-451 as an inflammatory regulator, is poorly understood. In this regard, this microRNA (miRNA)
Karimi-Sales Elham +4 more
doaj +5 more sources
Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice [PDF]
Archives of Endocrinology and Metabolism, 2015 Objective Acarbose and trans-chalcone are glucosidase inhibitors whose beneficial effects have been demonstrated in diabetes. The present study aimed at investigating their potential effects in obesity.Materials and methods NMRI male mice (n = 48) were ...
Fatemeh Jalalvand +4 more
doaj +5 more sources
Exploring the Therapeutic Potential of trans-Chalcone: Modulation of MicroRNAs Linked to Breast Cancer Progression in MCF-7 Cells. [PDF]
Int J Mol Sci, 2023 Breast cancer is responsible for 25% of all cancers that affect women. Due to its high heterogeneity pattern in clinical diagnosis and its molecular profile differences, researchers have been seeking new targets and therapies, with more specificity and fewer side effects.
Komoto TT +10 more
europepmc +4 more sources
Regulation of autophagy-related gene expressions by Trans-chalcone in the lungs of adult male rats [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Autophagy is responsible for maintaining cellular homeostasis by degrading and recycling macromolecules and unwanted intracellular components, such as damaged organelles.
Fatemeh Salehi Mazdeh +4 more
doaj +3 more sources
Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism [PDF]
BMC Genomics, 2019 Background Trichophyton rubrum is the main etiological agent of skin and nail infections worldwide. Because of its keratinolytic activity and anthropophilic nature, infection models based on the addition of protein substrates have been employed to assess
Tamires Aparecida Bitencourt +11 more
doaj +2 more sources
Characterization of a Natural, Stable, Reversible and Colourful Anthocyanidin Network from Sphagnum Moss Based Mainly on the Yellow Trans-Chalcone and Red Flavylium Cation Forms [PDF]
Molecules, 2021 Anthocyanins with various functions in nature are one of the most important sources of colours in plants. They are based on anthocyanidins or 3-deoxyanthocyanidins having in common a C15-skeleton and are unique in terms of how each anthocyanidin is ...
Helge Berland, Øyvind M. Andersen
doaj +2 more sources
pH-Induced Orthogonal Photoresponse of trans-Chalcone Isomers and Related Compounds in Equilibria
Colorants, 2023 Photoresponsive molecular devices can be a valuable tool to promote chemical changes in response to multiple signals, such as photons and pH, to deliver drugs or to detect physiological conditions in vivo.
Jeonghee Kang +3 more
doaj +2 more sources
Electron Paramagnetic Resonance Study of the Radiation Damage in Trans-Chalcone Single Crystal
Acta Physica Polonica A, 2019 Gamma irradiated trans-chalcone (C15H12O) single crystals are investigated at 120 K using electron paramagnetic resonance technique. Trans-chalcone single crystals are irradiated with Co-60-gamma rays, at room temperature. The EPR spectra of gamma irradiated trans-chalcone single crystals are studied for different orientations of crystals in a magnetic
Çalışkan, Betül. +1 more
core +6 more sources
Evaluation of antifungal and cytotoxic activity of trans-Chalcone and α-Solanine [PDF]
BMC Proc, 2014 Background Dermatophytes are adapted to grow in keratinized tissues such as skin, nail and hair. Trichophyton rubrum is the most frequent cause of dermatophytosis in Brazil and in the world [1]. Despite its incidence there are only a limited number of antifungal drugs available for clinical use and some drugs are highly toxic to humans. In this regard,
Komoto T +5 more
europepmc +3 more sources
Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer. [PDF]
Toxicol Res, 2021 AbstractDespite intensive research efforts in recent decades, cancer remains a leading cause of death worldwide. The chalcone family is a promising group of phytochemicals for therapeutic use against cancer development. Naturally-occurring chalcones, as well as synthetic chalcone analogues, have shown many beneficial biological properties, including ...
Komoto TT +6 more
europepmc +4 more sources