Results 21 to 30 of about 736,450 (179)

Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone [PDF]

Chemical Communications, 2015
Sortase A (SrtA) from Gram positive pathogens is an attractive target for inhibitors due to its role in the attachment of surface proteins to the cell wall.
Wallock-Richards DJ, Marles-Wright J, Clarke DJ, Maitra A, Dodds M, Hanley B, Campopiano DJ   +6 more
openaire   +6 more sources

The solubility and stability of heterocyclic chalcones compared with trans-chalcone [PDF]

Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2020
Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one and (E)-3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one, are assessed.
Stephen G. Sweeting, Charlie L. Hall, Jason Potticary, Natalie E. Pridmore, Stephen D. Warren, Matthew E. Cremeens, Gemma D. D'Ambruoso, Masaomi Matsumoto, Simon R. Hall   +8 more
openaire   +5 more sources

<i>Trans</i>-Chalcone Reduces Inflammation and Pain Triggered by Superoxide Anion: Neuronal and Non-Neuronal Mechanisms. [PDF]

J Inflamm Res
Maiara Piva,1 Marília F Manchope,1,2 Fernanda Barbosa-Costa,1 Beatriz H S Bianchini,1 Ketlem C Andrade,1 Letícia Coelho Silva,1 Cássia Calixto-Campos,1 Fernanda S Rasquel-Oliveira,1,3 Victor Fattori,1,3 Ana Carla Zarpelon-Schutz,1 Doumit Camilios-Neto,4 Sergio M Borghi,1 Rubia Casagrande,5 Waldiceu A Verri1 1Department of Immunology, Parasitology ...
Piva M, Manchope MF, Barbosa-Costa F, Bianchini BHS, Andrade KC, Silva LC, Calixto-Campos C, Rasquel-Oliveira FS, Fattori V, Zarpelon-Schutz AC, Camilios-Neto D, Borghi SM, Casagrande R, Verri WA.   +13 more
europepmc   +3 more sources

Phytotoxic Potential of Trans-chalcone on Crop Plants and Model Species

Journal of Plant Growth Regulation, 2013
Peer ...
Elisa Grana, Manuel J Reigosa, Adela M Sánchez-Moreiras   +2 more
exaly   +3 more sources

Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels. [PDF]

Inflammopharmacology
Abstract Objective Trans -Chalcone (TC) is an anti-inflammatory flavonoid that reduces hyperalgesia by targeting nuclear factor κB and inflammasome in gout arthritis model. However, a direct modulation of nociceptors by TC has never been investigated,
Piva M, Yaekashi KM, Pereira TGO, Bertozzi MM, Pinho-Ribeiro FA, Calixto-Campos C, Camilios-Neto D, Borghi SM, Zarpelon-Schutz AC, Fattori V, Casagrande R, Verri WA.   +11 more
europepmc   +4 more sources

Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone

MethodsX
In this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content ...
J.R.S. Botelho, A. Caeiro, H.C. Sousa, M.E.M. Braga, M.G. Campos   +4 more
doaj   +2 more sources

A Way to Improve Luminescent Efficiency of Bis-Chalcone Derivatives [PDF]

Journal of Chemistry, 2016
Chalcone related compounds have been reported as a poor luminescence molecule due to the quenching processes from the intramolecular torsional motions and cis-trans isomerization in the α,β-unsaturated ketone moiety.
Meng Guan Tay, Mee Hing Tiong, Ying Ying Chia, Suzie Hui Chin Kuan, Zhi-Qiang Liu   +4 more
doaj   +2 more sources

Trans-Chalcone Plus Baicalein Synergistically Reduce Intracellular Amyloid Beta (Aβ₄₂) and Protect from Aβ₄₂ Induced Oxidative Damage in Yeast Models of Alzheimer's Disease. [PDF]

Int J Mol Sci, 2021
Finding an effective therapeutic to prevent or cure AD has been difficult due to the complexity of the brain and limited experimental models. This study utilized unmodified and genetically modified Saccharomyces cerevisiae as model organisms to find ...
Dhakal S, Ramsland PA, Adhikari B, Macreadie I.   +3 more
europepmc   +2 more sources

trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders.
Elham Karimi-Sales, Mohammad Reza Alipour   +1 more
doaj   +1 more source

The Effect of Trans-Chalcone on Amylase Activity, Blood Glucose and Lipid Levels in Diabetic and Non Diabetic Rats

Armaghane Danesh Bimonthly Journal, 2011
Introduction & Objective: Alpha amylase is the most important decomposing enzyme in starch. Digestion and absorption of starch in the intestine can be prevented and also the blood sugar levels can be controlled by restrain and control of alpha amylase ...
M Najafian, A Ebrahim-Habibi, P Yaghmaei, K Parivar, B Larijani   +4 more
doaj   +1 more source