Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice [PDF]
Archives of Endocrinology and Metabolism, 2015 Objective Acarbose and trans-chalcone are glucosidase inhibitors whose beneficial effects have been demonstrated in diabetes. The present study aimed at investigating their potential effects in obesity.Materials and methods NMRI male mice (n = 48) were ...
Fatemeh Jalalvand +4 more
doaj +5 more sources
Regulation of autophagy-related gene expressions by Trans-chalcone in the lungs of adult male rats [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Autophagy is responsible for maintaining cellular homeostasis by degrading and recycling macromolecules and unwanted intracellular components, such as damaged organelles.
Fatemeh Salehi Mazdeh +4 more
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Trans-chalcone suppresses tumor growth mediated at least in part by the induction of heme oxygenase-1 in breast cancer [PDF]
Toxicological Research, 2021 AbstractDespite intensive research efforts in recent decades, cancer remains a leading cause of death worldwide. The chalcone family is a promising group of phytochemicals for therapeutic use against cancer development. Naturally-occurring chalcones, as well as synthetic chalcone analogues, have shown many beneficial biological properties, including ...
Tatiana Takahasi Komoto +2 more
exaly +4 more sources
Protective Role of trans-Chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451 [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder and an aggressive form of fatty liver disease. Certain microRNAs, including miR-122, 21, 34a, and 451, are involved in the transition from steatosis to NASH.
Elham Karimi-Sales +3 more
doaj +2 more sources
Chalcone and Trans-Chalcone Induce Transcriptomic Changes in Caenorhabditis elegans Compatible with a Novel Cumulative Damage Mode of Action [PDF]
MoleculesChalcones, a subclass of flavonoid-derived phenolic compounds, have demonstrated promising anthelmintic activity against parasitic nematodes. This study aimed to obtain insights into the biological effects a cis/trans mixture of chalcone and its ...
Giulio Galli +5 more
doaj +2 more sources
Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism [PDF]
BMC Genomics, 2019 Background Trichophyton rubrum is the main etiological agent of skin and nail infections worldwide. Because of its keratinolytic activity and anthropophilic nature, infection models based on the addition of protein substrates have been employed to assess
Tamires Aparecida Bitencourt +11 more
doaj +2 more sources
Characterization of a Natural, Stable, Reversible and Colourful Anthocyanidin Network from Sphagnum Moss Based Mainly on the Yellow Trans-Chalcone and Red Flavylium Cation Forms [PDF]
Molecules, 2021 Anthocyanins with various functions in nature are one of the most important sources of colours in plants. They are based on anthocyanidins or 3-deoxyanthocyanidins having in common a C15-skeleton and are unique in terms of how each anthocyanidin is ...
Helge Berland, Øyvind M. Andersen
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Evaluation of antifungal and cytotoxic activity of trans-Chalcone and α-Solanine [PDF]
BMC Proceedings, 2014 Background Dermatophytes are adapted to grow in keratinized tissues such as skin, nail and hair. Trichophyton rubrum is the most frequent cause of dermatophytosis in Brazil and in the world [1]. Despite its incidence there are only a limited number of antifungal drugs available for clinical use and some drugs are highly toxic to humans. In this regard,
Komoto, Tatiana +5 more
openaire +2 more sources
Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone [PDF]
Chemical Communications, 2015 Sortase A (SrtA) from Gram positive pathogens is an attractive target for inhibitors due to its role in the attachment of surface proteins to the cell wall.
Wallock-Richards DJ +6 more
openaire +6 more sources
Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels [PDF]
InflammopharmacologyAbstract Objective Trans -Chalcone (TC) is an anti-inflammatory flavonoid that reduces hyperalgesia by targeting nuclear factor κB and inflammasome in gout arthritis model. However, a direct modulation of nociceptors by TC has never been investigated,
Piva, Maiara +11 more
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