Results 31 to 40 of about 736,450 (179)

Cytotoxic Profiling of 3',4',5'-Trimethoxychalcones Reveals Cell-Line-Dependent Cytotoxic Activity: An In Vitro and In Silico Study. [PDF]

Chem Biodivers
A systematic evaluation of 3′,4′,5′‐trimethoxychalcones reveals potent yet strongly cell‐line‐dependent cytotoxic activity across multiple cancer models. Despite high potency, no universal structure–activity relationships emerge. Combined in vitro and in silico analyses indicate a multifactorial, context‐dependent mode of action, underscoring the need ...
Mehandzhiyski AY, Beraich A, Velkov Z, Zaharieva M, Konstantinov S, Batovska D.   +5 more
europepmc   +2 more sources

Novel chalcone-based fluorescent human histamine H 3 receptor ligands as pharmacological tools [PDF]

, 2012
Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif.
Miriam Tomasch, Lilia Weizel, Weizel, Lilia, Stark, Holger, Tomasch, Miriam, Holger Stark, Schwed, J. Stephan, J. Stephan Schwed   +7 more
core   +1 more source

Figure S6. The ER resident protein DapA does not reallocate in presence of trans-chalcone.

, 2023
Figure S6. The ER resident protein DapA does not reallocate in presence of trans-chalcone. Fluorescence microscopy was performed with the sdeA::GFP and dapA::GFP strain (SJX29, kindly provided by Dr. Ling Liu - Nanjing Normal University, China).
Iran Malavazi (14855818)
core   +1 more source

Theoretical Study on the Conformational Equilibrium of 1’, 2' and 3'-Nitro-4-hydroxy-3-methoxy Chalcone Isomers

Orbital: The Electronic Journal of Chemistry, 2021
This paper presents the conformational analysis of three chalcone compounds, 1'-nitro-4-hydroxy-3-metoxychalcoea (o-CHAL), 2'-nitro-4-hydroxy-3-metoxychalcone (m-CHAL) and 3'-nitro-4-hydroxiy3-metoxychalcone (p-CHAL).
Hualace Vinicius Emiliano, Thiago de Castro Rozada, Raphaela Pereira Guaringue, Barbara Celânia Fiorin   +3 more
doaj   +3 more sources

Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines

Molecules, 2018
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity.
Tatiana Takahasi Komoto, Tayná Minervina Bernardes, Thaís Balthazar Mesquita, Luis Felipe Buso Bortolotto, Gabriel Silva, Tamires Aparecida Bitencourt, Seung Joon Baek, Mozart Marins, Ana Lúcia Fachin   +8 more
doaj   +1 more source

The synthesis of chiral β-naphthyl-β-sulfanyl ketones via enantioselective sulfa-Michael reaction in the presence of a bifunctional cinchona/sulfonamide organocatalyst

Beilstein Journal of Organic Chemistry, 2021
Cinchona alkaloid-derived organocatalysts are widely employed in various asymmetric transformations, yielding products with high enantiopurity. In this respect, a bifunctional quinine-derived sulfonamide organocatalyst was developed to catalyze the ...
Deniz Tözendemir, Cihangir Tanyeli
doaj   +1 more source

Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives [PDF]

, 2022
Chalcones have been well examined in the extant literature and demonstrated antibacterial, antifungal, anti-inflammatory, and anticancer properties.
Nurolaini Kifli, -, Andi Hermansyah, Mei Jun Loy, Hossain, Md. Sanower, Ming, Long Chiau, Mei Jun Loy, -, Jagjit Singh Dhaliwa, -, Dhaliwal, Sachinjeet Kaur Sodhi, Khang Wen Goh, -, Yassin, Hayati, Hayati Yassin, Md. Sanower Hossain, Hossain, Md Sanower, Said Moshawih, -, Dhaliwal, Jagjit Singh, Sachinjeet Kaur Sodhi Dhaliwal, -, Pg Hj Md Yassin, Hayati, Hui Poh Goh, Kotra, Vijay, Vijay, Kotra, Vijay Kotra, -, Nurolaini Kifli, Goh, Khang Wen, Moshawih, Said, Said Moshawih, Long Chiau Ming, -, Vijay Kotra, Khang Wen Goh, Long Chiau Ming, Sachinjeet Kaur Sodhi Dhaliwal, Hermansyah, Andi, Sodhi Dhaliwal, Sachinjeet Kaur, Sanower Hossain, -, Loy, Mei Jun, Hayati Yassin, -, Goh, Hui Poh, Andi Hermansyah, -, Jagjit Singh Dhaliwal, Kifli, Nurolaini, Hui Poh Goh, -   +39 more
core   +1 more source

Machine Learning Accelerates Crystallization for Structure Determination

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Single‐crystal X‐ray diffraction (SCXRD) is often constrained by the difficulty of obtaining suitable crystals. Here, a machine learning‐accelerated co‐crystal discovery workflow is established for a crystalline mate strategy that achieves over 95% prediction accuracy and experimentally delivers 114 co‐crystals from 120 candidates.
Cui‐Zhou Luan, Xue‐Zhi Wang, Jian‐Guo Song, Yu Gu, Jing Wu, Ye‐Ting Wang, Jin‐Feng Liang, Jia‐Le Rao, Mo Xie, Jonathan R. Nitschke, Dan Li   +10 more
wiley   +2 more sources

(E)-3-(4-Methylphenyl)-1-(1,3-thiazol-2-yl)prop-2-en-1-one

Acta Crystallographica Section E, 2012
In the title chalcone, C13H11NOS, derived from the condensation of p-tolualdehyde and 1-(1,3-thiazol-2-yl)ethanone, the olefine group has a trans configuration. No classical hydrogen bonding is present in the crystal structure.
Annamalai Palaniappan, Arumugam Arulmozhivarman, Rajamanickam Ramachandran, Subramanian Srinivasan, Sivakolunthu Senthan   +4 more
doaj   +1 more source

A simple and rapid spectrophotometric method for the determination of trans-chalcone in raw-material and topical formulation

Semina: Ciências Biológicas e da Saúde, 2023
Trans-chalcone (TC) is a flavonoid precursor characterized by a wide spectrum of action, with anti-inflammatory and antioxidant effects. However, no validated methods are available in official compendia for the analysis of this substance. Thus, the aim of this work was to develop and validate a simple, fast, and reproducible spectrophotometric method ...
Renata Martinez, Nathalia Yurika Fukuda, Jenifer Freitas da Silva, Clara Ruiz de Souza, Sandra Regina Georgetti, Marcela Maria Baracat, Rúbia Casagrande   +6 more
openaire   +1 more source