Results 1 to 10 of about 114,148 (343)

Elevations in Liver Transaminases in COVID-19: (How) Are They Related?

Frontiers in Medicine, 2021
Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease.
Henrique Pott-Junior, Natália Queiroz Prado Bittencourt, Silvana F. G. Chacha, Rafael Luís Luporini, Rafael Luís Luporini, Marcia Regina Cominetti, Fernanda de Freitas Anibal, Fernanda de Freitas Anibal   +7 more
doaj   +2 more sources

Elevated Transaminases: Does It Always Warrant a Liver Biopsy? Lessons Learned From Pompe Disease [PDF]

JIMD Reports
Pompe disease (PD) is an autosomal recessive disorder caused by pathogenic variants in GAA, resulting in acid alpha‐glucosidase (GAA) deficiency and lysosomal glycogen accumulation.
Alicia Khazzeka, Rebecca L. Koch, Jeong‐A. Lim, Jeremy D. Ward, Jessica Doxey, William R. Jeck, Priya S. Kishnani   +6 more
doaj   +2 more sources

Using Steady-State Kinetics to Quantitate Substrate Selectivity and Specificity: A Case Study with Two Human Transaminases

Molecules, 2022
We examined the ability of two human cytosolic transaminases, aspartate aminotransferase (GOT1) and alanine aminotransferase (GPT), to transform their preferred substrates whilst discriminating against similar metabolites.
Alessio Peracchi, Eugenia Polverini
doaj   +1 more source

Role of Nutrition in the Etiopathogenesis and Prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in a Group of Obese Adults

Medicina, 2023
Nonalcoholic fatty liver disease (NAFLD) is liver damage characterized by an accumulation of triglycerides in hepatocytes of >5% (due to an alteration of the balance of the lipid metabolism in favour of lipogenesis compared to lipolysis) that is not ...
Daniela Metro, Martina Buda, Luigi Manasseri, Francesco Corallo, Davide Cardile, Viviana Lo Buono, Angelo Quartarone, Lilla Bonanno   +7 more
doaj   +1 more source

Structure- and Data-Driven Protein Engineering of Transaminases for Improving Activity and Stereoselectivity.

Angewandte Chemie, 2023
Amine transaminases (ATAs) are powerful biocatalysts for the stereoselective synthesis of chiral amines. Machine learning provides a promising approach for protein engineering, but activity prediction models for ATAs remain elusive due to the difficulty ...
Y. Ao, Shuxin Pei, Chao Xiang, Marian J. Menke, Lin Shen, Chenghai Sun, M. Dörr, Stefan Born, M. Höhne, U. Bornscheuer   +9 more
semanticscholar   +1 more source

Effects of folic acid supplementation on liver enzymes, lipid profile, and insulin resistance in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Advanced Biomedical Research, 2023
Background: Previous evidence revealed an association between folate deficiency and non-alcoholic fatty liver disease (NAFLD). This study is the first one investigating the effects of folic acid on hepatic steatosis grade, liver enzymes, insulin ...
Mohamad Reza Molaqanbari, Shadi Zarringol, Hamid Reza Talari, Mohsen Taghizadeh, Fereshteh Bahmani, Abbas Mohtashamian, Armin Ebrahimzadeh, Nasrin Sharifi   +7 more
doaj   +1 more source

To the Understanding of Catalysis by D-Amino Acid Transaminases: A Case Study of the Enzyme from Aminobacterium colombiense

Molecules, 2023
Pyridoxal-5′-phosphate (PLP)-dependent transaminases are highly efficient biocatalysts for stereoselective amination. D-amino acid transaminases can catalyze stereoselective transamination producing optically pure D-amino acids.
S. A. Shilova, M. Khrenova, I. O. Matyuta, A. Nikolaeva, T. Rakitina, N. Klyachko, M. Minyaev, K. Boyko, V. Popov, E. Y. Bezsudnova   +9 more
semanticscholar   +1 more source

Comparison of Four Immobilization Methods for Different Transaminases

Catalysts, 2023
Biocatalytic syntheses often require unfavorable conditions, which can adversely affect enzyme stability. Consequently, improving the stability of biocatalysts is needed, and this is often achieved by immobilization.
Tobias Heinks, Nicolai Montua, Michelle Teune, Jan Liedtke, M. Höhne, U. Bornscheuer, G. Fischer von Mollard   +6 more
semanticscholar   +1 more source

Detoxification of Fumonisins by Three Novel Transaminases with Diverse Enzymatic Characteristics Coupled with Carboxylesterase

Foods, 2023
Fumonisin (FB) is one of the most common mycotoxins contaminating feed and food, causing severe public health threat to human and animals worldwide.
Yue Wang, Jun-mao Sun, Mengwei Zhang, Kungang Pan, Tianhui Liu, Tongcun Zhang, Xuegang Luo, Junqi Zhao, Zhongyuan Li   +8 more
semanticscholar   +1 more source

Study of Carotid Atherosclerosis in Non-alcoholic Fatty Liver Disease Patients and Its Correlation With Serum Transaminases. [PDF]

Cureus
Aggarawal AK, Deepak A.
europepmc   +3 more sources