Results 181 to 190 of about 114,148 (343)

Impact of statins on liver transaminases in patients with metabolic dysfunction-associated steatotic liver disease: A 12-month retrospective review. [PDF]

Hepatol Forum
Wong PJW, Ng SC, George S, Rasdi RB.
europepmc   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Corrigendum: Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

Frontiers in Pediatrics
Mirela Luminița Pavelescu, Mirela Luminița Pavelescu, Alexandru Dinulescu, Alexandru Dinulescu, Alexandru-Sorin Păsărică, Irina Dijmărescu, Irina Dijmărescu, Daniela Păcurar, Daniela Păcurar   +8 more
doaj   +1 more source

Anti-Tubercular Drug-Induced Liver Injury: Current Understanding and Emerging Directions. [PDF]

JGH Open
Prasad S, Narang H, Kedia S, Ahuja V.
europepmc   +1 more source

1072 LOWER CUT-OFF LIMIT FOR ALANINE TRANSAMINASE IS NOT EFFECTIVE IN EXCLUDING SIGNIFICANT HISTOLOGICAL DISEASE IN CHRONIC HEPATITIS C (HCV)

, 2010
Faisal M. Sanai, A. Abdo, C.S. Dale, Andrew Helmy, Khalid Bzeizi, Kazuhiro Katada, Hamad Al-Ashgar, H. Al-Husseini, Mohammed Alquaiz, Ahmed Hashim, H. Almana, M.H. Rajab, P. Marotta   +12 more
openalex   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Biocatalytic cascade combining an engineered pyranose 2-oxidase and transaminases for the synthesis of amino sugars. [PDF]

RSC Adv
Chuaboon L, Visitsatthawong S, Sookbampen O, Suthin S, Voss M, Wongnate T, Höhne M, Bornscheuer UT, Chaiyen P.   +8 more
europepmc   +1 more source

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

To PLP or Not to PLP: Stereodivergent Transaminase-Catalyzed Reactions Directed by Kinetic and Thermodynamic Control. [PDF]

J Org Chem
Fitzgerald MJ, Li X, Peng D, Qin C, Sun Y, Wang CC, Yeung Y, Nguyen C, Key HM.   +8 more
europepmc   +1 more source