Results 141 to 150 of about 5,008,846 (367)

Bacterial RNA polymerase-DNA interaction - the driving force of gene expression and the target for drug action

Frontiers in Molecular Biosciences, 2016
DNA-dependent multisubunit RNA polymerase (RNAP) is the key enzyme of gene expression and a target of regulation in all kingdoms of life. It is a complex multifunctional molecular machine which, unlike other DNA-binding proteins, engages in extensive and
Sergei Borukhov, Jookyung Lee
doaj   +1 more source

Shaping Robust System through Evolution

, 2008
Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the ...
de Visser J. A. G. M., Edwards A. W. F., Einstein A., Fisher R. A., Futuyma D. J., Kaneko K., Kirschner M. W., Kunihiko Kaneko, Schmalhausen I. I., Waddington C. H., West-Eberhard M. J.   +10 more
core   +1 more source

Survey of variation in human transcription factors reveals prevalent DNA binding changes

Science, 2016
Variation and transcription factor binding Little is known about the phenotypic and functional effects of genetic variants that result in amino acid changes within functional proteins. Barrera et al.
Luis A. Barrera, Anastasia Vedenko, Jesse V. Kurland, J. Rogers, Stephen S. Gisselbrecht, E. Rossin, Jaie C. Woodard, Luca Mariani, K. Kock, S. Inukai, T. Siggers, Leila Shokri, Raluca Gordân, Nidhi Sahni, C. Cotsapas, Tong Hao, S. Yi, Manolis Kellis, M. Daly, M. Vidal, D. Hill, M. Bulyk   +21 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

Nature Communications, 2017
Covariance of gene expression pairs is due to a combination of shared genetic and environmental factors. Here the authors estimate the genetic correlation between highly heritable pairs and identify transcription factor control and chromatin interactions
Samuel W. Lukowski, Luke R. Lloyd-Jones, Alexander Holloway, Holger Kirsten, Gibran Hemani, Jian Yang, Kerrin Small, Jing Zhao, Andres Metspalu, Emmanouil T. Dermitzakis, Greg Gibson, Timothy D. Spector, Joachim Thiery, Markus Scholz, Grant W. Montgomery, Tonu Esko, Peter M. Visscher, Joseph E. Powell   +17 more
doaj   +1 more source

Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability.

Frontiers in Genetics, 2015
DNA replication and transcription are vital cellular processes during which the genetic information is copied into complementary DNA and RNA molecules.
Alessandra eBrambati, Arianna eColosio, Luca eZardoni, Lorenzo eGalanti, Giordano eLiberi, Giordano eLiberi   +5 more
doaj   +1 more source

Roles of transposable elements in the regulation of mammalian transcription

Nature reviews. Molecular cell biology, 2022
Raquel Fueyo, Julius Judd, C. Feschotte, J. Wysocka   +3 more
semanticscholar   +1 more source

Deconstructing cell-free extract preparation for in vitro activation of transcriptional genetic circuitry

bioRxiv, 2018
Recent advances in cell-free gene expression (CFE) systems have enabled their use for a host of synthetic biology applications, particularly for rapid prototyping of genetic circuits designed as biosensors.
A. Silverman, N. Kelley-Loughnane, J. Lucks, M. Jewett   +3 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits [PDF]

arXiv, 2010
Non-genetic perturbations, such as environmental change or developmental noise, can induce novel phenotypes. If an induced phenotype confers a fitness advantage, selection may promote its genetic stabilization. Non-genetic perturbations can thus initiate evolutionary innovation.
arxiv