Results 171 to 180 of about 4,501,017 (312)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Mutagenesis of Highland barley (Hordeum vulgare L. Var. nudum) using nitrogen ion beam implantation: screening of phenotypic Var.ations and comparative transcriptome analysis. [PDF]

BMC Genomics
Yu HY, Zhang YH, Li H, Feng H.
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Yeast genetics: Genetic control mechanisms: transcriptional twisting [PDF]

Nature, 1986
openaire   +2 more sources

Development of PAM-flexible multiplex genome editors for enhancing cold-tolerance in indica rice

Crop Journal
The canonical CRISPR/Cas editors are constrained by the requirement for specific PAMs, which substantially limits their editable target range. Rice (particularly indica rice) is sensitive to low temperature, which impacts the yield and restricts the ...
Jiantao Tan, Kangli Sun, Qian Qian, Nan Chai, Xin Peng, Mengyuan Shen, Degui Zhou, Yao-Guang Liu, Qinlong Zhu, Qi Liu   +9 more
doaj  

Insight into the genetic underpinnings of tobacco hairy root formation by variant-associated genes based on whole-genome resequencing. [PDF]

Planta
Wu X, Zhu Z, Li P, Qi Z, Zhu R, Shi C.
europepmc   +1 more source

Disease variants alter transcription factor levels and methylation of their binding sites

Nature Genetics, 2016
M. Bonder, R. Luijk, D. Zhernakova, M. Moed, Patrick Deelen, M. Vermaat, M. van Iterson, F. van Dijk, M. van Galen, J. Bot, R. Slieker, P. M. Jhamai, M. Verbiest, H. Suchiman, M. Verkerk, R. van der Breggen, J. V. van Rooij, N. Lakenberg, W. Arindrarto, S. Kiełbasa, I. Jonkers, Peter van ’t Hof, I. Nooren, M. Beekman, J. Deelen, D. van Heemst, A. Zhernakova, E. Tigchelaar, M. Swertz, A. Hofman, A. Uitterlinden, R. Pool, J. van Dongen, J. Hottenga, C. Stehouwer, C. V. D. van der Kallen, C. Schalkwijk, L. H. van den Berg, E. V. van Zwet, H. Mei, Yang Li, M. Lemire, T. Hudson, P. Slagboom, C. Wijmenga, J. Veldink, M. V. van Greevenbroek, C. V. van Duijn, D. Boomsma, A. Isaacs, R. Jansen, J. V. van Meurs, P. ’. ’t Hoen, L. Franke, B. Heijmans   +54 more
semanticscholar   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Genome wide association analysis of flavour related metabolites in tea germplasm [Camellia sinensis (L.) Kuntze] from Assam using a genotyping by sequencing strategy. [PDF]

BMC Plant Biol
Konwar T, Sarma RN, Sarmah BK.
europepmc   +1 more source

Molecular and genetic control of plant thermomorphogenesis

Nature Plants, 2016
M. Quint, C. Delker, K. Franklin, P. Wigge, K. Halliday, M. V. Zanten   +5 more
semanticscholar   +1 more source