Results 171 to 180 of about 3,599,350 (306)

Activation of secondary metabolism in <i>Aspergillus</i> and related filamentous fungi through regulatory engineering. [PDF]

RSC Chem Biol
Shyong J, Wang CCC.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Genetic layout and genetic structure of the greenhouse whitefly Trialeurodes vaporariorum from Serbia

, 2019
Trialeurodes vaporariorum Westwood (Hemiptera: Aleyrodidae), a haplo-diploid sap feeding insect species, is a vector of many plant viruses and a serious polyphagous pest of greenhouse-grown vegetables and ornamental plants worldwide.
Drobnjaković, Tanja, Marčić, Dejan, Prijović, Mirjana, Banjanac, Tijana, Aleksić, Jelena   +4 more
core  

The origins of water conducting tissues as clues to bryophyte evolution. [PDF]

Plant Physiol
Gill AR.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

THE ROLE OF SOX2 AND SOX9 TRANSCRIPTION FACTORS IN THE REACTIVATION-RELATED FUNCTIONAL PROPERTIES OF NT2/D1- DERIVED ASTROCYTES

Astrocytes are the main homeostatic cells in the central nervous system. During reactive astrogliosis, these cells transform from quiescent into a reactive state by reacquiring some of the precursor properties.
Lazić, Andrijana, Popović, Jelena, Balint, Vanda, Stevanović, Milena, Perić, Mina, Stanisavljević Ninković, Danijela, Marjanović, Jelena, Dacić, Sanja   +7 more
core  

Glucose-TOR Signaling Regulates Root Hair Elongation in <i>Arabidopsis</i> via the RHD6-RSL4 Transcriptional Cascade. [PDF]

Plants (Basel)
Wang B, Zhang J, Yan W, Dai X, Zhang J, Zhang T, Deng K.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Cis- and trans-regulatory factors contributing to divergent activity of the TDH3 promoter in Saccharomyces yeast. [PDF]

Mol Biol Evol
Siddiq MA, Kania HP, Brown NJ, Wittkopp PJ.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source