Results 21 to 30 of about 3,753,914 (306)

Genetic determinants of neuroglobin transcription [PDF]

neurogenetics, 2013
Neuroglobin (NGB) is a neuron-specific vertebrate globin shown to protect against hypoxia, ischemia, oxidative stress and the toxic effects of Amyloid-beta. Following on our and others' results highlighting the importance of NGB expression in disease, we searched for genetic determinants of its expression.
R, Wang, E, Halper-Stromberg, M, Szymanski-Pierce, S S, Bassett, D, Avramopoulos   +4 more
openaire   +2 more sources

Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins

Frontiers in Microbiology, 2020
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha, Gajraj Singh Kushwaha, Anupam Patra, Neel Sarovar Bhavesh   +3 more
doaj   +1 more source

Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1

Scientific Reports, 2022
Herpesviruses are known to acquire several genes from their hosts during evolution. We found that a significant proportion of virus homologues encoded by HSV-1, HSV-2, EBV and KSHV and their human counterparts contain G-quadruplex motifs in their ...
Shivani Kumar, Chitteti Ramamurthy, Divya Choudhary, Aashika Sekar, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan   +6 more
doaj   +1 more source

Transcription of an Expanded Genetic Alphabet [PDF]

Journal of the American Chemical Society, 2009
Expansion of the genetic alphabet with a third base pair would have immediate biotechnology applications and also lay the foundation for a semisynthetic organism with an expanded genetic code. A variety of unnatural base pairs have been shown to be formed efficiently and selectively during DNA replication, and the pairs formed between the unnatural ...
Young Jun, Seo, Shigeo, Matsuda, Floyd E, Romesberg   +2 more
openaire   +2 more sources

Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12–1-9,11 cluster and HCMV miR-US33

BMC Molecular and Cell Biology, 2020
Background G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological role of G-quadruplexes have not been
Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan   +4 more
doaj   +1 more source

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

Heliyon, 2023
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer and accounts for about 95% of all head and neck cancers with high mortality, usually at a late stage.
Bolaji Fatai Oyeyemi, Urvinder S. Kaur, Amit Paramraj, Chintamani, Ravi Tandon, Abhinav Kumar, Neel Sarovar Bhavesh   +6 more
doaj   +1 more source

Evaluation of seaweed sulfated polysaccharides as natural antagonists targeting Salmonella typhi OmpF: molecular docking and pharmacokinetic profiling

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions.
Malaisamy Arunkumar, Murugan Mahalakshmi, Vairamuthu Ashokkumar, Manikka Kubendran Aravind, Sathaiah Gunaseelan, Verma Mohankumar, Balasubramaniem Ashokkumar, Perumal Varalakshmi   +7 more
doaj   +1 more source

Genetics in Light of Transcriptional Adaptation

Trends in Genetics, 2020
Genetics has recently benefited from the genome engineering revolution: genes can be knocked out, knocked down, or activated more easily than ever before. This range of genetic manipulations has also provided a range of outcomes, sometimes contradictory. But how much interesting biology hides within these discrepancies?
Kontarakis, Zacharias, Stainier, Didier Y.R.   +1 more
openaire   +4 more sources

Genetic Regulation of Transcription in the Endometrium in Health and Disease [PDF]

Frontiers in Reproductive Health, 2022
The endometrium is a complex and dynamic tissue essential for fertility and implicated in many reproductive disorders. The tissue consists of glandular epithelium and vascularised stroma and is unique because it is constantly shed and regrown with each menstrual cycle, generating up to 10 mm of new mucosa. Consequently, there are marked changes in cell
Mortlock, Sally, McKinnon, Brett, Montgomery, Grant W.   +2 more
openaire   +5 more sources

CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application

Life, 2021
CRISPR-based enzymes have offered a unique capability to the design of genetic switches, with advantages in designability, modularity and orthogonality.
Pei Du, Chunbo Lou, Xuejin Zhao, Qihui Wang, Xiangyu Ji, Weijia Wei   +5 more
doaj   +1 more source