Results 11 to 20 of about 1,566,033 (293)

Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1

Scientific Reports, 2022
Herpesviruses are known to acquire several genes from their hosts during evolution. We found that a significant proportion of virus homologues encoded by HSV-1, HSV-2, EBV and KSHV and their human counterparts contain G-quadruplex motifs in their ...
Shivani Kumar, Chitteti Ramamurthy, Divya Choudhary, Aashika Sekar, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan   +6 more
doaj   +1 more source

Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12–1-9,11 cluster and HCMV miR-US33

BMC Molecular and Cell Biology, 2020
Background G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological role of G-quadruplexes have not been
Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan   +4 more
doaj   +1 more source

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

Heliyon, 2023
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer and accounts for about 95% of all head and neck cancers with high mortality, usually at a late stage.
Bolaji Fatai Oyeyemi, Urvinder S. Kaur, Amit Paramraj, Chintamani, Ravi Tandon, Abhinav Kumar, Neel Sarovar Bhavesh   +6 more
doaj   +1 more source

Evaluation of seaweed sulfated polysaccharides as natural antagonists targeting Salmonella typhi OmpF: molecular docking and pharmacokinetic profiling

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions.
Malaisamy Arunkumar, Murugan Mahalakshmi, Vairamuthu Ashokkumar, Manikka Kubendran Aravind, Sathaiah Gunaseelan, Verma Mohankumar, Balasubramaniem Ashokkumar, Perumal Varalakshmi   +7 more
doaj   +1 more source

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]

, 2012
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul, Balschun, Tobias, Brand, Stephan, Czamara, Darina, Diegelmann, Julia, Duerr, Richard H., Franke, Andre, Glas, Jürgen, Kamboh, M. Ilyas, Müller-Myhsok, Bertram, Olszak, Torsten, Pasciuto, Giulia, Seiderer, Julia, Wetzke, Martin, Wolf, Christiane   +14 more
core   +8 more sources

CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application

Life, 2021
CRISPR-based enzymes have offered a unique capability to the design of genetic switches, with advantages in designability, modularity and orthogonality.
Pei Du, Chunbo Lou, Xuejin Zhao, Qihui Wang, Xiangyu Ji, Weijia Wei   +5 more
doaj   +1 more source

Transcription of an Expanded Genetic Alphabet [PDF]

Journal of the American Chemical Society, 2009
Expansion of the genetic alphabet with a third base pair would have immediate biotechnology applications and also lay the foundation for a semisynthetic organism with an expanded genetic code. A variety of unnatural base pairs have been shown to be formed efficiently and selectively during DNA replication, and the pairs formed between the unnatural ...
Young Jun, Seo, Shigeo, Matsuda, Floyd E, Romesberg   +2 more
openaire   +2 more sources

Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone [PDF]

, 2012
We performed a genetic association study of rare variants and single nucleotide polymorphisms (SNPs) of UCMA/GRP and OPTN genes, in French-Canadian patients with Paget's disease of bone (PDB) and in healthy controls from the same population.
Albagha, Albagha, Avilion, Basu-Roy, Cancela, Chen, Chung, Desmet, Edith Gagnon, Ethel S. Siris, Fahmi, Gabriel Miltenberger-Miltenyi, Goode, Hocking, Jacques P. Brown, Jean Morissette, Laurin, Laurin, Layfield, Laëtitia Michou, Le Jeune, Lefebvre, Lucas, Luu-The, M. Leonor Cancela, Maruyama, Michou, Morissette, Natércia Conceição, Pankiv, Rath, Rezaie, Rousiere, Shankar, Singh, Staden, Surmann-Schmitt, Tagariello, Tong, van Staa, Viegas, Viegas   +41 more
core   +1 more source

Transcription factor competition facilitates self-sustained oscillations in single gene genetic circuits.

PLoS Computational Biology, 2023
Genetic feedback loops can be used by cells to regulate internal processes or to keep track of time. It is often thought that, for a genetic circuit to display self-sustained oscillations, a degree of cooperativity is needed in the binding and unbinding ...
Jasper Landman, Sjoerd M Verduyn Lunel, Willem K Kegel   +2 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source