Results 41 to 50 of about 3,599,350 (306)
Genetic regulation of pituitary gland development in human and mouse [PDF]
, 2009 Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Robin Lovell-Badge +9 more
core +1 more source
Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. [PDF]
PLoS Biology, 2008 Previous studies in Saccharomyces cerevisiae have demonstrated that cryptic promoters within coding regions activate transcription in particular mutants.
Vanessa Cheung +6 more
doaj +1 more source
Transcriptional adaptation: a mechanism underlying genetic robustness [PDF]
Development, 2020 ABSTRACT Mutations play a crucial role in evolution as they provide the genetic variation that allows evolutionary change. Although some mutations in regulatory elements or coding regions can be beneficial, a large number of them disrupt gene function and reduce fitness. Organisms utilize several mechanisms to compensate for the damaging
Tamar E. Sztal, Didier Y. R. Stainier
openaire +2 more sources
MedProDB: A database of Mediator proteins
Computational and Structural Biotechnology Journal, 2021 In the last three decades, the multi-subunit Mediator complex has emerged as the key component of transcriptional regulation of eukaryotic gene expression.
Rohan Bhardwaj +2 more
doaj +1 more source
A survey of genetic improvement search spaces [PDF]
, 2019 Genetic Improvement (GI) uses automated search to improve existing software. Most GI work has focused on empirical studies that successfully apply GI to improve software's running time, fix bugs, add new features, etc. There has been little research into
Alexander, B +17 more
core +1 more source
Wheat Breeding, Transcription Factories, and Genetic Interactions: New Perspectives
Frontiers in Plant Science, 2022 Epistatic interactions and negative heterosis have been shown to be associated with interchromosomal interactions in wheat. Physical gene-gene interactions between co-regulated genes clustered in “transcription factories” have been documented, and a ...
Richard B. Flavell
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survivorship care plans (SCPs) summarize cancer treatment and guide risk‐based follow‐up for cancer survivors, yet remain difficult to create, share, and use. Stakeholder perspectives are needed to inform usable approaches.
Molly S. Talman +4 more
wiley +1 more source
Falling for the dark side of transcription: Nab2 fosters RNA polymerase III transcription. [PDF]
, 2016 RNA polymerase III (RNAPIII) synthesizes diverse, small, non-coding RNAs with many important roles in the cellular metabolism. One of the open questions of RNAPIII transcription is whether and how additional factors are involved.
Reuter, LM, Sträßer, K
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source