Results 61 to 70 of about 1,088,355 (314)
The Ultimate (Mis)match: When DNA Meets RNA
Cells, 2021 RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity.
Benoit Palancade, Rodney Rothstein
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Genetic and epigenomic mechanisms of mammalian circadian transcription [PDF]
Nature Structural & Molecular Biology, 2016 The mammalian molecular clock comprises a complex network of transcriptional programs that integrates environmental signals with physiological pathways in a tissue-specific manner. Emerging technologies are extending knowledge of basic clock features by uncovering their underlying molecular mechanisms, thus setting the stage for a 'systems' view of the
Romeo, Papazyan +2 more
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Transcription as source of genetic heterogeneity in budding yeast
Yeast, 2023 Transcription presents challenges to genome stability both directly, by altering genome topology and exposing single-stranded DNA to chemical insults and nucleases, and indirectly by introducing potential obstacles to the DNA replication machinery. Such obstacles include the RNA polymerase holoenzyme itself, DNA bound regulatory factors, G-quadruplexes
Baptiste Piguet, Jonathan Houseley
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Automatic transcription of polyphonic music exploiting temporal evolution [PDF]
, 2012 PhDAutomatic music transcription is the process of converting an audio recording into a symbolic representation using musical notation. It has numerous applications in music information retrieval, computational musicology, and the creation of ...
Emmanouil Benetos, Benetos, E
core
eLife, 2015 We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-
Romaric Bouveret +17 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Frontiers in Oncology, 2014 Meningiomas are frequent central nervous system neoplasms which despite their predominant benignity, show sporadically malignant behaviour. Type 2 Neurofibromatosis and polymorphisms in several genes have been associated with meningioma risk and are ...
Adrián eMosquera Orgueira +1 more
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Ancient mtDNA genetic variants modulate mtDNA transcription and replication. [PDF]
PLoS Genetics, 2009 Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the ...
Sarit Suissa +8 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source