Results 81 to 90 of about 3,753,914 (306)
Frontiers in Oncology, 2014 Meningiomas are frequent central nervous system neoplasms which despite their predominant benignity, show sporadically malignant behaviour. Type 2 Neurofibromatosis and polymorphisms in several genes have been associated with meningioma risk and are ...
Adrián eMosquera Orgueira +1 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The genetic regulation of transcription in human endometrial tissue [PDF]
Human Reproduction, 2017 Do genetic effects regulate gene expression in human endometrium?This study demonstrated strong genetic effects on endometrial gene expression and some evidence for genetic regulation of gene expression in a menstrual cycle stage-specific manner.Genetic effects on expression levels for many genes are tissue specific.
Fung, Jenny N. +10 more
openaire +4 more sources
Genetic architecture of gene transcription in two Atlantic salmon (Salmo salar) populations [PDF]
, 2017 Gene expression regulation has an important role in short-term acclimation and long-term adaptation to changing environments. However, the genetic architecture of gene expression has received much less attention than that of traditional phenotypic traits.
Pitcher, Trevor E. +7 more
core +1 more source
Frontiers in Plant Science, 2018 Transposable elements make important contributions to adaptation and evolution of their host genomes. The well-characterized transposase-derived transcription factor FAR-RED ELONGATED HYPOCOTYLS3 (FHY3) and its homologue FAR-RED IMPAIRED RESPONSE1 (FAR1)
Lin Ma, Lin Ma, Gang Li
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Genetic, Epigenetic and Transcription Factors in Atrial Fibrillation
Рациональная фармакотерапия в кардиологии, 2019 Atrial fibrillation (AF) is one of the most common arrhythmia that occurs in patients with cardiovascular diseases. Congenital forms of AF are quite rare.
O. V. Sapelnikov +6 more
doaj +1 more source
Ancient mtDNA genetic variants modulate mtDNA transcription and replication. [PDF]
PLoS Genetics, 2009 Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the ...
Sarit Suissa +8 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Genetic and epigenomic mechanisms of mammalian circadian transcription [PDF]
Nature Structural & Molecular Biology, 2016 The mammalian molecular clock comprises a complex network of transcriptional programs that integrates environmental signals with physiological pathways in a tissue-specific manner. Emerging technologies are extending knowledge of basic clock features by uncovering their underlying molecular mechanisms, thus setting the stage for a 'systems' view of the
Romeo, Papazyan +2 more
openaire +2 more sources