Results 91 to 100 of about 3,753,914 (306)

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms [PDF]

, 2011
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Stewart, B.J., Carnegie, P., Pain, G.N., Dawkins, R.L., Steele, E.J., Williamson, J.F., Lindley, R.A., Millman, J.A., Lester, S.   +8 more
core  

Chemical composition, antioxidant, antimicrobial, and anticancer activities of Mahonia napaulensis DC. bark from Nepal

BMC Complementary Medicine and Therapies
Background Cancer is one of the major health problems worldwide and medicinal plants constitute a common alternative for cancer treatment having no or fewer side effects.
Rajib Kumar Shrestha, Satyabrata Nayak, Prabal Singh Maharjan, Bivek Pokharel, Gagan Deep Jhingan, Rana Pratap Singh, Neel Sarovar Bhavesh, Bhupal Govinda Shrestha   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast [PDF]

, 2008
The association between transcription and DNA repair is acknowledged as a player in the generation of mutations in a non-random fashion in prokaryotes and eukaryotes.
Leonid Brodsky, Yefim Ronin, Abraham Korol, Eviatar Nevo, Aviv de Morgan, Yechezkel Kashi   +5 more
core  

Evolutionary conservation of the fidelity of transcription

Nature Communications, 2023
The molecular mechanisms that ensure faithful transcription of genetic information are still unclear. Chung et al. identify various genes, alleles and processes that affect the fidelity of transcription multiple organisms, suggesting evolutionary ...
Claire Chung, Bert M. Verheijen, Zoe Navapanich, Eric G. McGann, Sarah Shemtov, Guan-Ju Lai, Payal Arora, Atif Towheed, Suraiya Haroon, Agnes Holczbauer, Sharon Chang, Zarko Manojlovic, Stephen Simpson, Kelley W. Thomas, Craig Kaplan, Peter van Hasselt, Marc Timmers, Dorothy Erie, Lin Chen, Jean-Franćois Gout, Marc Vermulst   +20 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Dynamic analysis of stochastic transcription cycles [PDF]

, 2011
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses.
Davis, Julian R. E., Harper, Claire V., White, Michael R H, Mullins John J., Finkenstädt Bärbel, Davis, Julian R E, See Profile, Mullins, John J, Semprini Sabrina, John J Mullins, Harper Claire V., Sabrina Semprini, Davis Julian R. E., Finkenstaedt, Baerbel, Michael R H White, Friedrichsen, Soenke, Woodcock, Dan J., Spiller, David G., Rand, David A., Mullins, John J., Harper, Claire V; id_orcid, Spiller, David G.; id_orcid, Bärbel Finkenstädt, Woodcock Dan J., Julian R. E. Davis, Woodcock, Dan J, Spiller, David G, David A Rand, Friedrichsen Sönke, Julian R E Davis, David G. Spiller, Michael R. H. White, Ashall Louise, David A. Rand, Friedrichsen, Sönke, John J. Mullins, Dan J. Woodcock, Rand, D. A. (David A.), Spiller David G., White Michael R. H., White, Michael R. H., Louise Ashall, Sönke Friedrichsen, Semprini, Sabrina, Ashall, Louise, Rand, David A, David G Spiller, David A. R, Finkenstädt, Bärbel, Dan J Woodcock, Rand David A., Claire V. Harper, Claire V Harper   +52 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source