Results 191 to 200 of about 1,572,227 (290)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Brief Review on the Role of the Transcription Factor PBX1 in Hematologic Malignancies. [PDF]

Int J Mol Sci
Chatzileontiadou S, Boulogeorgou K, Frouzaki C, Papaioannou M, Koletsa T, Hatjiharissi E.   +5 more
europepmc   +1 more source

Transcriptional Regulation of Endothelial Cell Tissue Factor Expression during Rickettsia rickettsii Infection: Involvement of the Transcription Factor NF-κB [PDF]

, 1998
Rui-Jin Shi, Patricia J. Simpson‐Haidaris, Norma B. Lerner, Victor J. Marder, David J. Silverman, Lee Ann Sporn   +5 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Knockout of the OsNAC113 Transcription Factor Causes High Salt Resistance in Rice. [PDF]

Plants (Basel)
Wang B, Zhao X, Wang Q, Xu C, Qi X, Zhu Y, Lyu M, Wang Y, Chen C, Zhang Y.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transcription factor switching drives subtype-specific pancreatic cancer. [PDF]

Nat Genet
Rao SV, Young L, Cheeseman D, Flynn S, Krebs N, Couturier DL, Mack S, Brais R, Temple J, Smith A, Papachristou E, Pelicano C, Chilamakuri CSR, Herka K, Baba H, Farah L, Cheung PF, Siveke J, Guerrier S, Insolia L, Gill M, Archer Goode E, Kupczak S, Cheng Y, Borsari G, Jodrell D, D'Santos C, Russell A, Grünwald BT, Serrao E, Chernukhin I, Carroll JS.   +31 more
europepmc   +1 more source

57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation

, 2006
Jun Kondo, Fuyuki Sato, Katsumi Fujimoto, Tomomi Kusumi, Tadanobu Imanaka, Takeshi Kawamoto, Bhawal Uk, Mitsuhide Noshiro, Yukio Kato, Tatsusuke Sato, Hiroshi Kijima   +10 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A short SUMOylation tag modulates transcription factor activity. [PDF]

J Biol Chem
Bouchard AY, Vivet AJI, Cabana VC, Li C, Thibault P, Lussier MP, Mader S, Cappadocia L.   +7 more
europepmc   +1 more source