Results 41 to 50 of about 2,419,657 (375)
Structural basis of TFIIH activation for nucleotide excision repair. [PDF]
, 2019 Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH).
Chernev, A. +5 more
core +2 more sources
Structural fingerprints of transcription factor binding site regions [PDF]
, 2009 Fourier transforms are a powerful tool in the prediction of DNA sequence properties, such as the presence/absence of codons. We have previously compiled a database of the structural properties of all 32,896 unique DNA octamers.
Christopher Hunter +8 more
core +2 more sources
Extending the dynamic range of transcription factor action by translational regulation [PDF]
Phys. Rev. E 93, 022404 (2016), 2015 A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at their binding sites can severely limit the precision of regulation.
arxiv +1 more source
Transcription Factor KLF14 and Metabolic Syndrome
Frontiers in Cardiovascular Medicine, 2020 Metabolic syndrome (MetSyn) is a combination of metabolic abnormalities that lead to the development of cardiovascular disease (CVD) and Type 2 Diabetes (T2D).
Qianyi Yang, Mete Civelek, Mete Civelek
doaj +1 more source
A role for ATP-dependent chromatin remodeling in the hierarchical cooperativity between noninteracting transcription factors [PDF]
J. Theor. Biol. 287, 74-81 (2011), 2015 Chromatin remodeling machineries are abundant and diverse in eukaryotic cells. They have been involved in a variety of situations such as histone exchange and DNA repair, but their importance in gene expression remains unclear. Although the influence of nucleosome position on the regulation of gene expression is generally envisioned under the quasi ...
arxiv +1 more source
A patient‐derived explant (PDE) model of hormone‐dependent cancer
Molecular Oncology, 2018 Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the development of more clinically relevant models, such as organoids or murine xenografts that utilize ...
Margaret M. Centenera +19 more
doaj +1 more source
A transcription factor for cold sensation!
Molecular Pain, 2005 The ability to feel hot and cold is critical for animals and human beings to survive in the natural environment. Unlike other sensations, the physiology of cold sensation is mostly unknown.
Milbrandt Jeffrey +3 more
doaj +1 more source
How the DNA sequence affects the Hill curve of transcriptional response [PDF]
Phys. Biol. 9 (2012) 056006, 2011 The Hill coefficient is often used as a direct measure of the cooperativity of binding processes. It is an essential tool for probing properties of reactions in many biochemical systems. Here we analyze existing experimental data and demonstrate that the Hill coefficient characterizing the binding of transcription factors to their cognate sites can in ...
arxiv +1 more source
Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]
, 2012 DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry +62 more
core +3 more sources
Molecular Oncology, 2023 Transcription factors (TFs) are key players in the regulation of gene transcription in mammalian cells. Although high‐throughput screening can be used to identify differentially expressed genes between comparable groups, the precision of the ...
Fanchen Wang +7 more
doaj +1 more source