Results 41 to 50 of about 2,601,708 (287)

Target Finder of Transcription Factor (TFoTF): a novel tool to predict transcription factor‐targeted genes in cancer

Molecular Oncology, 2023
Transcription factors (TFs) are key players in the regulation of gene transcription in mammalian cells. Although high‐throughput screening can be used to identify differentially expressed genes between comparable groups, the precision of the ...
Fanchen Wang, Xiaolin Xu, Xin Li, Jia Yuan, Xuzhu Gao, Chenglong Wang, Wencai Guan, Guoxiong Xu   +7 more
doaj   +1 more source

Activating Transcription Factor 3 (ATF3) is a Highly Conserved Pro-regenerative Transcription Factor in the Vertebrate Nervous System

Frontiers in Cell and Developmental Biology, 2022
The vertebrate nervous system exhibits dramatic variability in regenerative capacity across species and neuronal populations. For example, while the mammalian central nervous system (CNS) is limited in its regenerative capacity, the CNS of many other ...
Hilary R. Katz, Anthony A. Arcese, Ona Bloom, Ona Bloom, Jennifer R. Morgan   +4 more
doaj   +1 more source

Pea3 transcription factor promotes neurite outgrowth

Frontiers in Molecular Neuroscience, 2014
Pea3 subfamily of ETS transcription factors consist of three major proteins, Pea3, ERM and ER81. Although important for many different tissues that exhibit branching morphogenesis, the function of Pea3 family in nervous system development and ...
BASAK eKANDEMIR, BERRAK eCAGLAYAN, BARBARA eHAUSOTT, BURCU eERDOGAN, UGUR eDAG, OZLEM eDEMIR, MELIS eSAVASAN SOGUT, Lars eKlimaschewski, ISIL eAKSAN KURNAZ   +8 more
doaj   +1 more source

Transcription factor p73 regulates Th1 differentiation

Nature Communications, 2020
Heterogeneous helper T (Th) cell responses contribute to differential susceptibility to immunological disorders. Here the authors perform haplotype-based computational screens of 16 inbred mouse strains to identify a transcription factor, p73, as an ...
Min Ren, Majid Kazemian, Ming Zheng, JianPing He, Peng Li, Jangsuk Oh, Wei Liao, Jessica Li, Jonathan Rajaseelan, Brian L. Kelsall, Gary Peltz, Warren J. Leonard   +11 more
doaj   +1 more source

Chlorophyllase is transcriptionally regulated by CsMYB308/CsDOF3 in young leaves of tea plant

Horticultural Plant Journal, 2023
Chlorophyll contributes to tea coloration, which is an important factor in tea quality. Chlorophyll metabolism is induced by light, but the transcriptional regulation responsible for light-induced chlorophyll metabolism is largely unknown in tea leaves ...
Weimin Liu, Siyan Liu, Kaiyue Zhang, Mingwei Xie, Haiwei Sun, Xiaoqin Huang, Lixia Zhang, Min Li   +7 more
doaj   +1 more source

Coding limits on the number of transcription factors [PDF]

, 2006
Transcription factor proteins bind specific DNA sequences to control the expression of genes. They contain DNA binding domains which belong to several super-families, each with a specific mechanism of DNA binding.
Alon, Uri, Itzkovitz, Shalev, Tlusty, Tsvi   +2 more
core   +4 more sources

RT‐PCR–Based Detection of Bone Marrow Involvement in Ewing Sarcoma: Diagnostic Validity and Prognostic Relevance

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background In Ewing sarcoma (EwS), metastases, including those to bone marrow (BM), are the main factors influencing prognosis. Although reverse transcription polymerase chain reaction (RT‐PCR) offers greater sensitivity, the current EWING protocol defines BM metastases solely using light microscopic detection.
Thanh Pham, Andreas Ranft, Victor Rechl, Susanne Jabar, Wolfgang Hartmann, Kim Falkenberg, Heribert Jürgens, Norbert Graf, Torsten Keßler, Markus Metzler, Thomas Klingebiel, Thorsten Simon, Martin Benesch, Uta Dirksen   +13 more
wiley   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism

Frontiers in Cell and Developmental Biology, 2021
Krüppel-like factor 9 (Klf9) is a feedforward regulator of glucocorticoid receptor (GR) signaling. Here we show that in zebrafish klf9 is expressed with GR-dependent oscillatory dynamics in synchrony with fkbp5, a GR target that encodes a negative ...
Ian M. Gans, Ian M. Gans, Janelle Grendler, Remy Babich, Nishad Jayasundara, James A. Coffman, James A. Coffman   +6 more
doaj   +1 more source

Dynamics of gene expression and the regulatory inference problem

, 2008
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times.
, Alon U., Chen W. England J. Shakhnovich E., Hertz J., Honerkamp J., J. Berg, Lèbre S., Michaelis L., Spellman P. T., Stokic D. Hanel R. Thurner S., van Kampen N.   +10 more
core   +1 more source