Results 61 to 70 of about 1,562,873 (242)
Transcription factors and asthma [PDF]
European Respiratory Journal, 1998 Asthma is characterized by the expression of multiple genes for inflammatory proteins, such as cytokines, enzymes, receptors and adhesion molecules. This is orchestrated by transcription factors, which are proteins that bind to the promoter regions of these genes and may be activated by inflammatory stimuli, such as cytokines.
Ian M. Adcock, Peter J. Barnes
openaire +3 more sources
The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2. [PDF]
PLoS ONE, 2013 SerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators ...
Ekemini A Udofa +6 more
doaj +1 more source
Fundamental Dynamic Units: Feedforward Networks and Adjustable Gates [PDF]
arXiv, 2009 The activation/repression of a given gene is typically regulated by multiple transcription factors (TFs) that bind at the gene regulatory region and recruit RNA polymerase (RNAP). The interactions between the promoter region and TFs and between different TFs specify the dynamic responses of the gene under different physiological conditions. By choosing
arxiv
Non-equilibrium dynamics of gene expression and the Jarzynski equality [PDF]
, 2007 In order to express specific genes at the right time, the transcription of genes is regulated by the presence and absence of transcription factor molecules. With transcription factor concentrations undergoing constant changes, gene transcription takes place out of equilibrium.
arxiv +1 more source
eLife, 2015 The σ subunit of bacterial RNA polymerase (RNAP) confers on the enzyme the ability to initiate promoter-specific transcription. Although σ factors are generally classified as initiation factors, σ can also remain associated with, and modulate the ...
Seth R Goldman +4 more
doaj +1 more source
Unsupervised learning of transcriptional regulatory networks via latent tree graphical models [PDF]
arXiv, 2016 Gene expression is a readily-observed quantification of transcriptional activity and cellular state that enables the recovery of the relationships between regulators and their target genes. Reconstructing transcriptional regulatory networks from gene expression data is a problem that has attracted much attention, but previous work often makes the ...
arxiv
A mouse tissue transcription factor atlas
Nature Communications, 2017 While we have abundant data for transcription factor (TF) binding sites and TF expression at the mRNA level, our knowledge of TFs at the protein level and their DNA-binding activities is sparser.
Quan Zhou +10 more
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BMC Plant Biology, 2020 Background R2R3-MYB transcription factors (TFs) play important roles in plant growth and development, and response to biotic and abiotic stresses. However, their regulatory mechanisms in wound-induced anthocyanin biosynthesis in woody plants are largely ...
Haihai Wang +5 more
doaj +1 more source
Transcription Factor Binding to Replicated DNA
Cell Reports, 2020 Summary: Genome replication perturbs the DNA regulatory environment by displacing DNA-bound proteins, replacing nucleosomes, and introducing dosage imbalance between regions replicating at different S-phase stages.
Raz Bar-Ziv +3 more
doaj
Frontiers in Genetics, 2018 Today, it is well-known that in eukaryotic cells the complex interplay of transcription factors (TFs) bound to the DNA of promoters and enhancers is the basis for precise and specific control of transcription.
Cornelia Meckbach +4 more
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