Results 61 to 70 of about 15,541,955 (379)

Dissection of a complex transcriptional response using genome‐wide transcriptional modelling

Molecular Systems Biology, 2009
Modern genomics technologies generate huge data sets creating a demand for systems level, experimentally verified, analysis techniques. We examined the transcriptional response to DNA damage in a human T cell line (MOLT4) using microarrays.
Martino Barenco, Daniel Brewer, Efterpi Papouli, Daniela Tomescu, Robin Callard, Jaroslav Stark, Michael Hubank   +6 more
doaj   +1 more source

The Sox2 transcription factor binds RNA

Nature Communications, 2020
Some transcription factors have been proposed to functionally interact with RNA to facilitate proper regulation of gene expression. Here the authors demonstrate that human Sox2 interact directly and with high affinity to RNAs through its HMG DNA-binding ...
Zachariah E. Holmes, Desmond J. Hamilton, Taeyoung Hwang, Nicholas V. Parsonnet, John L. Rinn, Deborah S. Wuttke, Robert T. Batey   +6 more
doaj   +1 more source

Target Finder of Transcription Factor (TFoTF): a novel tool to predict transcription factor‐targeted genes in cancer

Molecular Oncology, 2023
Transcription factors (TFs) are key players in the regulation of gene transcription in mammalian cells. Although high‐throughput screening can be used to identify differentially expressed genes between comparable groups, the precision of the ...
Fanchen Wang, Xiaolin Xu, Xin Li, Jia Yuan, Xuzhu Gao, Chenglong Wang, Wencai Guan, Guoxiong Xu   +7 more
doaj   +1 more source

Activating Transcription Factor 3 (ATF3) is a Highly Conserved Pro-regenerative Transcription Factor in the Vertebrate Nervous System

Frontiers in Cell and Developmental Biology, 2022
The vertebrate nervous system exhibits dramatic variability in regenerative capacity across species and neuronal populations. For example, while the mammalian central nervous system (CNS) is limited in its regenerative capacity, the CNS of many other ...
Hilary R. Katz, Anthony A. Arcese, Ona Bloom, Ona Bloom, Jennifer R. Morgan   +4 more
doaj   +1 more source

A single transcription factor promotes both yield and immunity in rice

Science, 2018
Flexible growth and immune responses in rice Plants that are fighting microbial pathogens often divert resources that could be used for growth into the immune response. For crops, this translates into lower yield when plant immunity is activated. Wang et
Jing Wang, Lian Zhou, Hui Shi, M. Chern, Hong Yu, Hong Yi, M. He, J. Yin, Xiaobo Zhu, Yan Li, Weitao Li, Jiali Liu, Jichun Wang, Xiaoqiong Chen, Hai Qing, Yuping Wang, Guifu Liu, Wenming Wang, Ping Li, Xianjun Wu, Lihuang Zhu, Jian-Min Zhou, P. Ronald, Shigui Li, Jiayang Li, Xuewei Chen   +25 more
semanticscholar   +1 more source

Transcription factor p73 regulates Th1 differentiation

Nature Communications, 2020
Heterogeneous helper T (Th) cell responses contribute to differential susceptibility to immunological disorders. Here the authors perform haplotype-based computational screens of 16 inbred mouse strains to identify a transcription factor, p73, as an ...
Min Ren, Majid Kazemian, Ming Zheng, JianPing He, Peng Li, Jangsuk Oh, Wei Liao, Jessica Li, Jonathan Rajaseelan, Brian L. Kelsall, Gary Peltz, Warren J. Leonard   +11 more
doaj   +1 more source

Chlorophyllase is transcriptionally regulated by CsMYB308/CsDOF3 in young leaves of tea plant

Horticultural Plant Journal, 2023
Chlorophyll contributes to tea coloration, which is an important factor in tea quality. Chlorophyll metabolism is induced by light, but the transcriptional regulation responsible for light-induced chlorophyll metabolism is largely unknown in tea leaves ...
Weimin Liu, Siyan Liu, Kaiyue Zhang, Mingwei Xie, Haiwei Sun, Xiaoqin Huang, Lixia Zhang, Min Li   +7 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms

Haematologica, 2010
Background Aberrant activation of tyrosine kinases, caused by either mutation or gene fusion, is of major importance for the development of many hematologic malignancies, particularly myeloproliferative neoplasms.
Thomas Ernst, Andrew Chase, Katerina Zoi, Katherine Waghorn, Claire Hidalgo-Curtis, Joannah Score, Amy Jones, Francis Grand, Andreas Reiter, Andreas Hochhaus, Nicholas C.P. Cross   +10 more
doaj   +1 more source

Dynamics of gene expression and the regulatory inference problem

, 2008
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times.
, Alon U., Chen W. England J. Shakhnovich E., Hertz J., Honerkamp J., J. Berg, Lèbre S., Michaelis L., Spellman P. T., Stokic D. Hanel R. Thurner S., van Kampen N.   +10 more
core   +1 more source