Results 131 to 140 of about 4,631,251 (249)

Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3

MedComm
Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug ...
Wenhua Kuang, Ruishen Zhuge, Ping Song, Letai Yi, Shujie Zhang, Ying Zhang, Yin Kwan Wong, Ruixing Chen, Junzhe Zhang, Yuanbo Wang, Dandan Liu, Zipeng Gong, Peili Wang, Xiangying Ouyang, Jigang Wang   +14 more
doaj   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Transcription factors involved in cold response in plants. [PDF]

, 2010
Studies in Arabidopsis have shown cold stress tolerance can be enhanced by manipulation of the CBF/DREB and ICE transcription factor genes. To date, few studies have investigated CBF and ICE genes in crops species such as barley. Using a C-repeat element
Pillman, Katherine
core  

Regenerative Injection Laryngoplasty With Scaffold‐Forming Oligomer and Autologous Motor Endplate‐Expressing Cells: A 6‐Month Porcine Study

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Injection laryngoplasty is a standard‐of‐care intervention for unilateral vocal fold paralysis (UVFP), offering minimally invasive medialization with limited durability. We evaluated a regenerative injectable approach integrating an immunotolerant scaffold‐forming collagen (Oligomer) with autologous motor‐endplate expressing (MEE ...
Gabriel G. Sobczak, Rachel A. Morrison, Lujuan Zhang, Patrick R. Finnegan, Benjamin Johnson, Eric Dong, Bailey Egan, Aditya Bhatt, Sherry L. Voytik‐Harbin, Stacey Halum   +9 more
wiley   +1 more source

Nuciferine Ameliorates Ovariectomy-Induced Bone Loss via TFEB-Mediated Autophagy-Lysosomal Pathway

Biomolecules
Background: Postmenopausal osteoporosis is a common metabolic bone disease that leads to reduced bone formation and increased fracture risk. Nuciferine, an aporphine alkaloid from the lotus leaf, can regulate the TFEB-mediated autophagy-lysosomal pathway.
Beilei Shi, Ze Gao, Shih-Yu Chen, Jianbing Chen, Liangxu Wei, Wen Fan, Zhiqian Yang, Ying Zhang, Yan Cui, Xiaofeng Zhu   +9 more
doaj   +1 more source

TP53 mutations orchestrate partial EMT states in oral squamous cell carcinoma: spatially resolved and in vitro preliminary insights into tumour plasticity

The Journal of Pathology, EarlyView.
Abstract TP53 is the most frequently mutated gene in oral squamous cell carcinoma (OSCC); however, its role in promoting epithelial–mesenchymal transition (EMT) and tumour progression remains unclear, particularly within the context of intra‐tumour heterogeneity.
Rana Alaaeldin Ibrahim, Hong Wan, Raju Kumar, Muy‐Teck Teh, Angray Kang, Emma Bailey, Hannah Cottom, Adrian Biddle, Inês Sequeira, Farida Fortune   +9 more
wiley   +1 more source

Two centuries of Begonia exploration in the Philippines: Progress and challenges associated with a megadiverse genus in the Global South

PLANTS, PEOPLE, PLANET, EarlyView.
Megadiverse genera represent the highest concentration of plant diversity, but these plants are also located primarily in countries in the Global South where huge gaps in botanical knowledge remain. This study summarized two centuries of Begonia collection records in the Philippines to show how historical events coincide with collection and taxonomic ...
Mark Angelo C. Bucay, EB Perez‐Bellen, Marjorie D. Delos Angeles, Danilo N. Tandang, Rosario R. Rubite, Kuo‐Fang Chung   +5 more
wiley   +1 more source

A perspective on autophagy and transcription factor EB in Alcohol-Associated Alzheimer's disease. [PDF]

Biochem Pharmacol, 2023
Zhang C, Chen H, Rodriguez Y, Ma X, Swerdlow RH, Zhang J, Ding WX.   +6 more
europepmc   +1 more source

Tale of two transcription factors: NF-кB and HIF crosstalk [PDF]

, 2013
Hypoxia-inducible factor is a key transcriptional factor involved in the cellular response to low levels of oxygen, hypoxia. Moreover, hypoxia-inducible factor has been recently associated with a role in inflammation and immunity.
Rocha, S., Bandarra, D.
core  

Liquiritigenin Ameliorates High‐Fat Diet‐Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2‐ATGL Regulation

Phytotherapy Research, EarlyView.
Liquiritigenin promotes expression of CGI‐58 and enhances lipolysis by down‐regulating expression of PLIN2, thereby facilitating the catabolism of larger‐sized lipid droplets and producing smaller‐sized lipid droplets, resulting in enhanced activity of lipophagy and ameliorated hepatic steatosis. ABSTRACT Metabolic‐associated fatty liver disease (MAFLD)
Zhuoya Xu, Jingmiao Chen, Hong Qin, Yansong Fu, Cunqi Lv, Zhipeng Wang, Xi Liu, Wenya Zheng   +7 more
wiley   +1 more source