Results 161 to 170 of about 4,631,251 (249)

The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload. [PDF]

Int J Mol Sci, 2022
Wundersitz S, Pablo Tortola C, Schmidt S, Oliveira Vidal R, Kny M, Hahn A, Zanders L, Katus HA, Sauer S, Butter C, Luft FC, Müller OJ, Fielitz J.   +12 more
europepmc   +1 more source

Authentic and functional dialogue with AI‐based student avatars: Evidence from a practice‐based teacher education program

British Journal of Educational Technology, EarlyView.
Abstract Interactions with AI‐based student avatars offer scalable opportunities to practice educational dialogue in practice‐based teacher education (PBTE), yet little is known about the interaction quality of such simulations. This exploratory case study examined whether avatar‐mediated exchanges provide authentic and functional learning ...
Dennis Hauk, Franziska Menter, Jan‐Michael Schorling   +2 more
wiley   +1 more source

Endothelial Transcription Factor EB Protects Against Doxorubicin-Induced Endothelial Toxicity and Cardiac Dysfunction. [PDF]

Circulation
Du W, Ringer M, Desai D, Khandakar GI, Tron Esqueda LE, Wang C, Guan JL, Becker RC, Sadayappan S, Fan GC, Wang Y, Fan Y.   +11 more
europepmc   +1 more source

Loss of transcription factor EB dysregulates the G1/S transition and DNA replication in mammary epithelial cells. [PDF]

J Biol Chem, 2022
Slade L, Biswas D, Kienesberger PC, Pulinilkunnil T.   +3 more
europepmc   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

N-acetyl-L-leucine normalizes Transcription Factor EB activity by stereospecific bidirectional modulation in a HeLa cell model of Niemann-Pick disease type C. [PDF]

PLoS One
Davis LC, Annaert W, Braine R, Churchill GC, Factor M, Fields T, Patterson M, Platt F, Shepherd D, Strupp M, Galione A.   +10 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Protocol for monitoring the stability of transcription factor EB using global protein stability assay. [PDF]

STAR Protoc
Wang B, Zhao Y, Li R, Li X, Dong C, Mi W, Wang X.   +6 more
europepmc   +1 more source

Peroxisome proliferator-activated receptor γ activation ameliorates liver fibrosis-differential action of transcription factor EB and autophagy on hepatocytes and stellate cells. [PDF]

Hepatol Commun, 2023
Yum YJ, Yoo J, Bang K, Jun JE, Jeong IK, Ahn KJ, Chung HY, Hwang YC.   +7 more
europepmc   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source