Results 171 to 180 of about 38,959 (207)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Stathmin‐2 mediates paracrine hormone regulation of glucagon through lysosomal trafficking in αTC1‐6 cells

The Journal of Physiology, EarlyView.
Abstract figure legend Paracrine regulation of glucagon involves Stathmin2‐mediated trafficking of glucagon through lysosomal transport. Glucagon secretion is regulated by the paracrine hormones insulin and somatostatin. We postulate that insulin enhances lysosomal transport of glucagon away from sites of exocytosis, and somatostatin functions in the ...
Nelson Chang, Samuel Ugulini, Savita Dhanvantari   +2 more
wiley   +1 more source

Predicting Relevant Microglia‐Associated Cell–Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1

Glia, Volume 74, Issue 10, October 2026.
We used CellChat to infer altered cell–cell communication in Alzheimer's disease Microglia signal to each other via SPP1 in Alzheimer's disease. SPP1‐expressing microglia are present around amyloid‐β plaques. ABSTRACT Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease ...
Janssen M. Kotah, Marina Trombetta Lima, Esmée C. Dragt, Asimenia Voulgaroglou, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen   +7 more
wiley   +1 more source

Towards System Changes: Experiences of General Practitioners and Nurses in Facilitating Appointments and Referrals for Africans from Refugee Backgrounds in Australia

Health Promotion Journal of Australia, Volume 37, Issue 4, October 2026.
ABSTRACT Objective This study explored the experiences of general practitioners (GPs) and nurses working in specialised refugee health services when facilitating specialist hospital appointments and referrals for Africans from refugee backgrounds in Australia. Methods An exploratory‐descriptive, qualitative study was conducted.
Prince Peprah, Emmanuel Brenyah Adomako, Dipti Zachariah, David Ajak Ajang   +3 more
wiley   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Drought stress modulates indirect defense via bottom‐up effects in tomato and wheat

Pest Management Science, Volume 82, Issue 9, Page 8499-8511, September 2026.
Different water regimes can have a significant impact on plant morphology and defense pathways in tomato and wheat, triggering multiple olfactory choices in biocontrol agents of key insect pests. These findings could be used to implement biocontrol strategies within the IPM context under a changing climate scenario.
Mariangela Milordo, Eya Ben Hmad, Maria Flavia Pitruzzello, Carmelo Cavallaro, Giuseppe Massimino Cocuzza, Lucia Zappalà, Peng Han, Antonio Biondi, Michele Ricupero   +8 more
wiley   +1 more source

Making Decisions or Enacting Shoulder Care? Challenging Assumptions About Matters of Concern in the Orthopaedic Shoulder Clinic

Sociology of Health &Illness, Volume 48, Issue 7, September 2026.
ABSTRACT Because of increasing pressure on healthcare resources in many countries, public health policies are increasingly occupied with how to optimise decision‐making processes to ensure medical interventions are appropriate, necessary and aligned with the preferences and values of patients.
Anna Louise Skovgaard, Brian Elmengaard, David Høyrup Christiansen, Mette Terp Høybye   +3 more
wiley   +1 more source

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Aging Cell, Volume 25, Issue 9, September 2026.
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong‐en Wang, Qianjin Guo, You Zhang, Jiawei Wu, Huiyun Xu   +10 more
wiley   +1 more source