Results 171 to 180 of about 35,051 (207)

Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

2022
AbstractMany transcription factors (TFs) translocate to the nucleus with varied dynamic patterns in response to different inputs. A notable example of such behavior is RelA, a subunit of NF-κB, which translocates to the nucleus with either pulsed or sustained dynamics, depending on the stimulus.
Lindsey C. Osimiri, Alain R. Bonny, Seesha R. Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann, Hana El-Samad   +6 more
openaire   +1 more source

Catalytic domain of deubiquitinylase USP48 directs interaction with Rel homology domain of nuclear factor kappaB transcription factor RelA

Molecular Biology Reports, 2019
The activity and close regulation of nuclear factor kappaB (NF-κB) transcription factors is critical for a variety of cellular processes including inflammation, immunity, differentiation and cell survival. Thus, dysregulation of the NF-κB system could lead to serious diseases, e.g.
Ahmed Ghanem, Katrin Schweitzer, Michael Naumann   +2 more
openaire   +2 more sources

Expression of constitutively active Nuclear-κB RelA transcription factor in blasts of acute myeloid leukemia

Human Pathology, 2004
The nuclear transcription factor NF-kappa B regulates cell survival, proliferation, and differentiation. Little is known about NF-kappa B in myeloid malignancies. In this report, we assessed NF-kappa B in a group of myeloid neoplasms by using an electrophoretic mobility shift assay (EMSA) and immunofluorescence methods in freshly isolated leukemia ...
Carlos E, Bueso-Ramos, Frederico C, Rocha, Shishir, Shishodia, L Jeffrey, Medeiros, Hagop M, Kantarjian, Saroj, Vadhan-Raj, Zeev, Estrov, Terry L, Smith, Martin H, Nguyen, Bharat B, Aggarwal   +9 more
openaire   +2 more sources

Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3

Pathology - Research and Practice
To explore the biological function of RELA proto-oncogene, NF-kB subunit (RELA) in hepatocellular carcinoma (HCC) progression, and its potential regulatory effects on the regulators of m6A modification.GEPIA, UALCAN and Human Protein Atlas databases were applied to analyze the expression characteristics of RELA in HCC tissues and non-cancer liver ...
Jianguo, Wu, Weixing, Wang, Yongbin, Zheng, Wenhong, Deng, Jiasheng, Liu   +4 more
openaire   +2 more sources

The DEAD‐box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB‐mediated transcription

Journal of Cellular Biochemistry, 2008
AbstractDEAD‐box RNA helicases constitute the largest family of RNA helicases and are involved in many aspects of RNA metabolism. In this study, we identified RelA (p65), a subunit of nuclear factor‐kappaB (NF‐κB), as a cellular co‐factor of DEAD‐box RNA helicase DDX1, through mammalian two hybrid system and co‐immunoprecipitation assay.
Musarat, Ishaq, Li, Ma, Xiaoyun, Wu, Yongxin, Mu, Ji'an, Pan, Jiajie, Hu, Tao, Hu, Qiong, Fu, Deyin, Guo   +8 more
openaire   +2 more sources

Lipopolysaccharide activates ERK–PARP-1–RelA pathway and promotes nuclear factor–κB transcription in murine macrophages

Human Immunology, 2012
Poly(ADP-ribosyl)ation, like acetylation, methylation and phosphorylation, is one of the essential post-translational protein modifications. Poly(ADP-ribose) polymerase 1 (PARP-1), the best characterized member of the PARP family, catalyzes PAR formation, and has been implemented in the in vivo and in vitro inflammatory disease models.
Linlin, Liu, Yueshuang, Ke, Xue, Jiang, Fen, He, Lang, Pan, Li, Xu, Xianlu, Zeng, Xueqing, Ba   +7 more
openaire   +2 more sources

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3+ regulatory T cells

Journal of Autoimmunity, 2016
The properties of CD4(+) regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show the NF-κB transcription factor RelA is constitutively active in naïve and effector Tregs.
Nicole, Messina, Thomas, Fulford, Lorraine, O'Reilly, Wen Xian, Loh, Jessica M, Motyer, Darcy, Ellis, Catriona, McLean, Haroon, Naeem, Ann, Lin, Raffi, Gugasyan, Robyn M, Slattery, Raelene J, Grumont, Steve, Gerondakis   +12 more
openaire   +2 more sources

RelA/NF-kappaB transcription factor associates with alpha-actinin-4.

Experimental cell research, 2008
The NF-kappaB/RelA family of transcription factors regulates inducible transcription of a large number of genes in response to diverse stimuli. Little is known, however, about the location of NF-kappaB in the cytoplasm and the transport mechanism to the nucleus. We found that NF-kappaB is associated with the actin-binding protein alpha-actinin-4.
Vladimir N, Babakov, Olga A, Petukhova, Lidia V, Turoverova, Irina V, Kropacheva, Dmitri G, Tentler, Anastasia V, Bolshakova, Ekaterina P, Podolskaya, Karl-Eric, Magnusson, George P, Pinaev   +8 more
openaire   +1 more source