Results 71 to 80 of about 15,143,293 (401)

Prunus transcription factors: Breeding perspectives

Frontiers in Plant Science, 2015
Many plant processes depend on differential gene expression, which is generally controlled by complex proteins called transcription factors (TFs). In peach, 1,533 TFs have been identified, accounting for about 5.5% of the 27,852 protein-coding genes ...
Valmor João Bianchi, Manuel eRubio, Livio eTrainotti, Ignazio eVerde, Claudio eBonghi, Pedro eMartinez-Gomez   +5 more
doaj   +1 more source

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity [PDF]

, 2012
T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide
Mortazavi, Ali, Rothenberg, Ellen V., Williams, Brian A., Wold, Barbara J., Zhang, Jingli A.   +4 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

eLife, 2020
Because chromatin determines whether information encoded in DNA is accessible to transcription factors, dynamic chromatin states in development may constrain how gene regulatory networks impart embryonic pattern.
Isabella V Soluri, Lauren M Zumerling, Omar A Payan Parra, Eleanor G Clark, Shelby A Blythe   +4 more
doaj   +1 more source

Research advances of MYB transcription factors in plant stress resistance and breeding

Plant Signalling & Behavior, 2019
Plants face various stresses during the growth and development processes. The specific transcription factors bind to the cis-acting elements upstream of the stress resistance genes, specifically regulating the expression of the gene in plants and ...
Jinlu Li, Guoliang Han, Cuifeng Sun, N. Sui   +3 more
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Distinct transcriptomic features are associated with transitional and mature B-cell populations in the mouse spleen

Frontiers in Immunology, 2015
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets.
Eden eKleiman, Daria eSalyakina, Magali eDe Heusch, Magali eDe Heusch, Kristen L Hoek, Joan M Llanes, Iris eCastro, Jacqueline A Wright, Emily S Clark, Derek Michael Dykxhoorn, Akiko eTakeda, Enrico eCapobianco, Jean-Christophe eRenauld, Jean-Christophe eRenauld, Wasif N Khan   +14 more
doaj   +1 more source

Sensitivity of transcription factors to DNA methylation

Essays in Biochemistry, 2019
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the ...
Éléa Héberlé, A. Bardet
semanticscholar   +1 more source

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos. [PDF]

, 2018
The regulation of transcription requires the coordination of numerous activities on DNA, yet how transcription factors mediate these activities remains poorly understood.
Darzacq, Xavier, Eisen, Michael B, Hannon, Colleen E, Harrison, Melissa M, Mir, Mustafa, Ortiz, Stephan A, Stadler, Michael R   +6 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source