Results 61 to 70 of about 4,117,946 (252)

Dynamic analysis of stochastic transcription cycles [PDF]

, 2011
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses.
Davis, Julian R. E., Harper, Claire V., White, Michael R H, Mullins John J., Finkenstädt Bärbel, Davis, Julian R E, See Profile, Mullins, John J, Semprini Sabrina, John J Mullins, Harper Claire V., Sabrina Semprini, Davis Julian R. E., Finkenstaedt, Baerbel, Michael R H White, Friedrichsen, Soenke, Woodcock, Dan J., Spiller, David G., Rand, David A., Mullins, John J., Harper, Claire V; id_orcid, Spiller, David G.; id_orcid, Bärbel Finkenstädt, Woodcock Dan J., Julian R. E. Davis, Woodcock, Dan J, Spiller, David G, David A Rand, Friedrichsen Sönke, Julian R E Davis, David G. Spiller, Michael R. H. White, Ashall Louise, David A. Rand, Friedrichsen, Sönke, John J. Mullins, Dan J. Woodcock, Rand, D. A. (David A.), Spiller David G., White Michael R. H., White, Michael R. H., Louise Ashall, Sönke Friedrichsen, Semprini, Sabrina, Ashall, Louise, Rand, David A, David G Spiller, David A. R, Finkenstädt, Bärbel, Dan J Woodcock, Rand David A., Claire V. Harper, Claire V Harper   +52 more
core   +1 more source

The Magnitude of Dyslipidemia and Factors Associated with Elevated LDL-C Among Black South Africans with Type 2 Diabetes Mellitus at a Tertiary Hospital

Obesities
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a major global public health challenge with a significant impact on human life. The current study aims to provide a comprehensive analysis of the magnitude of dyslipidemia and the factors ...
Mashudu Nemukula, Siphesihle Mkhwanazi, Tumelo Jessica Mapheto, Arun Kumar Malaisamy, Neel Sarovar Bhavesh, Olebogeng Harold Majane, Sechene Stanley Gololo   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Role of Nocardia sp. bioactives in regulating the key molecular checkpoints in quorum-sensing pathways of P. aeruginosa: application towards improved fabrication of medical devices

Journal of Global Antimicrobial Resistance
AIM: Understanding the inhibitory role of bioactives from a novel Nocardia sp. against P. aeruginosa's Quorum-Sensing (QS) regulatory pathways and fabrication of effective foley catheters. BACKGROUND: P.
Saniya Zaidi, Nitin Srivastava, Moumita Ghosh, Deepti Jain, Sunil K. Khare, Paras N. Prasad   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

CMTM6 mediates the Warburg effect and promotes the liver metastasis of colorectal cancer

Experimental and Molecular Medicine
Liver metastasis of colorectal cancer (CRC) is a leading cause of death among cancer patients. The overexpression of glucose transporter 1 (Glut1) and enhanced glucose uptake that are associated with the Warburg effect are frequently observed in CRC ...
Aurpita Shaha, Yuanguo Wang, Xianghu Wang, Dong Wang, David Guinovart, Bin Liu, Ningling Kang   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

On the mechanistic nature of epistasis in a canonical cis-regulatory element

eLife, 2017
Understanding the relation between genotype and phenotype remains a major challenge. The difficulty of predicting individual mutation effects, and particularly the interactions between them, has prevented the development of a comprehensive theory that ...
Mato Lagator, Tiago Paixão, Nicholas H Barton, Jonathan P Bollback, Călin C Guet   +4 more
doaj   +1 more source