Results 41 to 50 of about 4,117,946 (252)

Optogenetic regulation of transcription

BMC Neuroscience, 2018
Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels.
Oksana Polesskaya, Ancha Baranova, Sarah Bui, Nikolai Kondratev, Evgeniya Kananykhina, Olga Nazarenko, Tatyana Shapiro, Frances Barg Nardia, Vladimir Kornienko, Vikas Chandhoke, Istvan Stadler, Raymond Lanzafame, Max Myakishev-Rempel   +12 more
doaj   +1 more source

Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation

Frontiers in Cell and Developmental Biology, 2021
Trans-differentiation of quiescent hepatic stellate cells (HSC) into myofibroblast cells is considered the linchpin of liver fibrosis. A myriad of signaling pathways contribute to HSC activation and consequently liver fibrosis.
Xiaoyan Wu, Xiaoyan Wu, Xiaoyan Wu, Wenhui Dong, Tianyi Zhang, Haozhen Ren, Haozhen Ren, Jinglin Wang, Jinglin Wang, Longcheng Shang, Zhengyi Zhu, Wei Zhu, Xiaolei Shi, Xiaolei Shi, Yong Xu, Yong Xu   +15 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Systems Biology of Transcription Regulation

, 2016
Transcription regulation is a complex process that can be considered and investigated from different perspectives. Traditionally and due to technical reasons (including the evolution of our understanding of the underlying processes) the main focus of the
Linde, Joerg, Joerg Linde, Edgar Wingender, Wingender, Edgar, Ekaterina Shelest, Shelest, Ekaterina   +5 more
core   +1 more source

Global Analysis of the Relationship between JIL-1 Kinase and Transcription [PDF]

, 2010
The ubiquitous tandem kinase JIL-1 is essential for Drosophila development. Its role in defining decondensed domains of larval polytene chromosomes is well established, but its involvement in transcription regulation has remained controversial.
Regnard Catherine, Peter B Becker, Mitterweger Angelika, Ina K. Dahlsveen, Becker Peter B., Tobias Straub, Straub, Tobias, Peter B, Regnard, Catherine, Fabian Viola, Mitterweger, Angelika, Ina K Dahlsveen, Peter B. Becker, Dahlsveen Ina K., Becker, Peter B., Fabian, Viola, Dahlsveen, Ina K., Catherine Regnard, Angelika Mitterweger, Viola Fabian, Straub Tobias   +20 more
core   +2 more sources

Structure of the Nipah virus polymerase phosphoprotein complex

Nature Communications
The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study
Ge Yang, Dong Wang, Bin Liu
doaj   +1 more source

PfAP2-EXP2, an Essential Transcription Factor for the Intraerythrocytic Development of Plasmodium falciparum

Frontiers in Cell and Developmental Biology, 2022
Plasmodium falciparum undergoes a series of asexual replications in human erythrocytes after infection, which are effective targets for combatting malaria.
Xiaomin Shang, Xiaomin Shang, Changhong Wang, Li Shen, Fei Sheng, Xiaohui He, Xiaohui He, Fei Wang, Yanting Fan, Xiaoqin He, Mei Jiang   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves [PDF]

, 2013
A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf senescence and stress responses. ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes
Cooke, Emma J., Jonathan D. Moore, Laura Bowden, Katherine J. Denby, Hickman, Richard J., Beynon, Jim, Richard Hickman, Findlay Bewicke‐Copley, David L. Wild, Vicky Buchanan‐Wollaston, Jim Beynon, Jackson, Alison C., Denby, Katherine J., Mead, A. (Andrew), Penfold, Christopher A., Bowden, Laura, Andrew Mead, Wild, David L., Christopher A. Penfold, Moore, Jonathan D., Emily Breeze, Breeze, Emily, Alison Jackson, Sascha Ott, Buchanan-Wollaston, Vicky, Peijun Zhang, Emma Cooke, Hill, C., Zhang, Peijun, Bewicke-Copley, Findlay, Claire Hill, Ott, Sascha, Moore, J.D., Bewick-Copley, F., Wild, D.L., Jackson, A., Bowden, L., Ott, S., Breeze, E., Cooke, E., Zhang, P., Penfold, C.A., Buchanan-Wollaston, V., Hickman, R., Mead, A., Beynon, J., Denby, K.J.   +46 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source