Results 31 to 40 of about 4,117,946 (252)
Structural insights into the Nipah virus nucleocapsid assembly
Communications BiologyNipah virus (NiV), a lethal zoonotic henipavirus, poses a major public health threat. Its nucleoprotein (N) safeguards the genome by forming a nucleocapsid, which, together with the RNA-dependent RNA polymerase (L) and phosphoprotein (P), constitutes the
Ge Yang +3 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Metabolic control through the PGC-1 family of transcription coactivators [PDF]
, 2005 Many complex biological programs are controlled at the level of gene transcription by DNA binding transcription factors. Recent studies have revealed a novel mode of regulation by coactivator proteins, best illustrated by the PGC-1 family of coactivators.
Lin, J. +5 more
core +1 more source
Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519
Nature CommunicationsERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding ...
Dong Wang, Fan Bu, Ge Yang, Bin Liu
doaj +1 more source
mSphere, 2022 Shigella is an Escherichia coli pathovar that colonizes the cytosol of mucosal cells in the human large intestine. To do this, Shigella uses a Type III Secretion Apparatus (T3SA) to translocate several proteins into host cells.
Navoun Silué +1 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Regulation of breast tumour cell survival by AP-2 transcription factors [PDF]
, 2010 PhDAP-2 transcription factors are crucial regulators of embryonic development and also play important roles in human neoplasia. Over-expression of AP-2α and AP-2γ in primary breast cancer (BC) correlates with expression of two major breast markers ...
Chan, Ka Yi Viona
core +3 more sources
Structure of the measles virus ternary polymerase complex
Nature CommunicationsMeasles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising
Dong Wang, Ge Yang, Bin Liu
doaj +1 more source
Regulation of HPV transcription
Clinics, 2018 Human papillomavirus infection is associated with the development of malignant and benign neoplasms. Approximately 40 viral types can infect the anogenital mucosa and are categorized into high- and low-risk oncogenic human papillomavirus, depending on ...
Aline Lopes Ribeiro +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source